Haholo-holo e arotsoe ka lithethefatsi tsa MEDICAL POLYPEPTIDE, lithibela-mafu tsa peptide, liente, li-peptide tse thibelang likokoana-hloko tsa temo, li-peptide tsa lijo, litlolo tsa lik'hemik'hale tsa letsatsi le letsatsi, li-peptide tsa SOYBEAN bakeng sa lijo, li-peptide tsa CORN, li-peptide tsa tomoso, li-peptide tsa likomkomere tsa leoatle.
Ho latela pono ea ts'ebetso, e ka aroloa ka peptide ea antihypertensive, peptide ea antioxidant, peptide e theolang k'holeseterole, peptide e sebetsang ea opioid, oligopeptide ea boleng bo phahameng ba F, peptide ea tatso ea lijo joalo-joalo.
Peptide e sebetsang, e nang le phepo e nepahetseng, hormone, inhibition ea enzyme, taolo ea 'mele ea ho itšireletsa mafung, antibacterial, antiviral, antioxidant e na le kamano e haufi haholo. Li-peptide ka kakaretso li arotsoe ka: lithethefatsi tsa peptide le lihlahisoa tsa bophelo tsa peptide. Lithethefatsi tsa setso tsa peptide haholo-holo ke lihomone tsa peptide. Tlhahiso ea litlhare tsa peptide e entsoe mafapheng a fapaneng a thibelo le taolo ea mafu, haholo-holo mafapheng a latelang.
Anti-tumor polypeptide
Tumorigenesis ke phello ea lintlha tse ngata, empa qetellong e kenyelletsa taolo ea polelo ea oncogene. Liphatsa tsa lefutso tse ngata tse amanang le hlahala le lintlha tsa taolo li fumanoe ka 2013. Li-peptide tsa ho hlahloba tse tlamang ka ho khetheha liphatsa tsa lefutso tsena le lintlha tsa taolo li fetohile sebaka se secha sa ho batla lithethefatsi tsa anticancer. Ka mohlala, somatostatin e 'nile ea sebelisoa ho phekola lihlahala tsa endocrine tsa tsamaiso ea lijo; Bafuputsi ba Amerika ba fumane hexapeptide e ka thibelang haholo adenocarcinoma ka vivo; Bo-rasaense ba Switzerland ba sibolotse octapeptide e susumetsang apoptosis liseleng tsa tumor.
Antiviral polypeptide
Ka ho tlama li-receptor tse itseng liseleng tse amohelang, livaerase li hohela lisele mme li itšetlehe ka li-protease tsa tsona tse ikhethileng bakeng sa ts'ebetso ea protheine le ho ikatisa ha nucleic acid. Ka hona, li-peptide tse tlamellang ho amohela li-cell receptors kapa libaka tse sebetsang joalo ka viral proteases li ka hlahlojoa ho tsoa laebraring ea peptide bakeng sa kalafo ea antiviral. Ka 2013, Canada, Italy le linaha tse ling li hlahlobile li-peptide tse ngata tse nyane tse nang le ho hanyetsa mafu ho tsoa laebraring ea peptide, 'me tse ling tsa tsona li kene sethaleng sa liteko tsa tleliniki. Ka June 2004, Setsi sa Microbiology, Sechaena Academy of Sciences se tlalehile hore tataiso ea bohlokoa ea morero oa ntlafatso ea tsebo e entsoeng ke Institute of Microbiology, Chinese Academy of Sciences, "Lipatlisiso ka mochine oa SARS-CoV cell fusion le Fusion inhibitors", e neng e entsoe ka kopanelo ke Setsi sa Microbiology, Sekolo sa Machaena sa Mahlale le Setsi sa Thuto-pele ea Likokoana-hloko, Life Sciences, Univesithi ea Wuhan, li ne li entse tsoelo-pele e kholo. Liteko li pakile hore peptide e etselitsoeng HR2 e ka thibela ts'oaetso ea lisele tse hlahisitsoeng ke vaerase ea SARS, mme ts'ebetso e sebetsang ea inhibition e maemong a li-nmoles tse 'maloa. Khatelo-pele ea bohlokoa e boetse e entsoe litekong tsa thibelo ea tšoaetso ea kokoana-hloko ea peptide e entsoeng le e hlahisitsoeng ea HR1 le liteko tsa in vitro tse tlamang tsa HR1 le HR2. Lithethefatsi tsa peptide tse etselitsoeng ho thibela ho kopana ha kokoana-hloko ea SARS li ka thibela tšoaetso ea kokoana-hloko, 'me ho bakuli ba nang le tšoaetso, li thibela ho ata ha kokoana-hloko 'meleng. Setlhare sa polypeptide se na le mesebetsi ea thibelo le ea kalafo. Bafuputsi Setsing sa Lipatlisiso sa Boenjiniere ba Lisele sa Univesithi ea Bongaka ea Sesole ea Bone ba entse li-peptide tse robong tse ka thibelang le ho thibela tlhaselo ea vaerase ea SARS liseleng.
Li-cytokine li etsisa li-peptide
Tšebeliso ea li-receptors bakeng sa li-cytokine tse tsejoang ho shebella li-cytokine li etsisa ho tloha lilaebraring tsa peptide e se e le sebaka sa ho etsa lipatlisiso ka 2011. Ho hlahlojoa ke batho ba linaheng tse ling erythropoietin, batho ba matlafatsa hormone ea platelet, hormone ea ho hōla, ho hōla ha methapo ea kutlo le hore mefuta e sa tšoaneng ea kgolo e kang interleukin - 1 ketsiso ea peptide, ketsiso ea tatellano ea amino acid ea peptide le selefouno e tsamaisanang le eona e fapane, tatellano ea li-amino acid empa e na le ts'ebetso ea li-cytokine, 'me e na le melemo ea tse nyane.boima ba molek'hule. Ka 2013 li-peptide tsena tse etsisang cytokine li tlas'a lipatlisiso tsa pele kapa tsa bongaka.
Peptide e sebetsang ea antibacterial
Ha likokoanyana li hlohlelletsoa ke tikoloho e ka ntle, ho hlahisoa palo e kholo ea li-peptide tsa cationic tse nang le ts'ebetso ea antibacterial. Ka 2013, mefuta e fetang 100 ea li-peptide tsa antimicrobial e se e hlahlobiloe. Liteko tsa in vitro le in vivo li netefalitse hore li-peptide tse ngata tsa antimicrobial ha li na matla a matla a antibacterial le bactericidal, empa hape li ka bolaea lisele tsa hlahala.
Ente ea peptide
Liente tsa peptide le liente tsa nucleic acid e ne e le e 'ngoe ea lintlha tsa bohlokoa ka ho fetisisa lefapheng la lipatlisiso tsa ente ka 2013. Lipatlisiso tse ngata le nts'etsopele ea liente tsa kokoana-hloko ea peptide li ile tsa etsoa lefatšeng ka 2013. Ka mohlala, ka 1999, NIH e hatisitse liphetho tsa liteko tsa bongaka tsa mefuta e 'meli ea liente tsa kokoana-hloko ea HIV-I ho batho; Polypeptide e ile ea hlahlojoa ho tsoa protheine e ka ntle ea membrane E2 ea kokoana-hloko ea lefu la sebete la C (HCV), e ka susumetsang 'mele ho hlahisa li-antibodies. United States e hlahisa ente ea malaria polyvalent antigen polypeptide; Ente ea papillomavirus peptide ea motho bakeng sa mofetše oa popelo e kene litekong tsa bongaka tsa mohato oa II. China e boetse e entse mosebetsi o mongata lipatlisisong tsa mefuta e fapaneng ea liente tsa polypeptide.
Li-peptide bakeng sa ho hlahlojoa
Tšebeliso e ka sehloohong ea li-peptide ho li-reagents tsa ho hlahloba ke li-antigens, li-antibodies ho lemoha likokoana-hloko tse tsamaisanang le likokoana-hloko. Li-antigen tsa polypeptide li tobile ho feta likokoana-hloko tsa tlhaho kapa li-antigen tsa protheine ea likokoana-hloko 'me li bonolo ho li lokisetsa. Li-reagents tsa ho lemoha li-antibody tse kopantsoeng le li-antigen tsa polypeptide ka 2013 li kenyelletsa: kokoana-hloko ea lefu la sebete la A, B, C, G, HIV, cytomegalovirus ea motho, kokoana-hloko ea herpes simplex, kokoana-hloko ea rubella, Treponema pallidum, cysticercosis, trypanosoma, lefu la Lyme le li-reagents tsa ho lemoha lefu la ramatiki. Boholo ba li-antigen tsa peptide tse sebelisitsoeng li fumanoe ho tsoa protheine ea tlhaho ea 'mele o tsamaisanang oa pathogenic,' me tse ling e ne e le li-peptide tse ncha tse fumanoeng laebraring ea peptide.
