Tesamorelin peptide (INN) (orukọ iṣowo Egrifta) jẹ ẹya sintetiki ti homonu idagba-hormone-tusilẹ homonu (GHRH) eyiti o lo ni itọju ti lipodystrophy ti o ni ibatan HIV, ti a fọwọsi ni ibẹrẹ ni 2010. O ti ṣe ati idagbasoke nipasẹ Theratechnologies, Inc. ti Canada. Oogun naa jẹ peptide sintetiki ti o ni gbogbo awọn amino acids 44 ti GHRH eniyan pẹlu afikun ti ẹgbẹ trans-3-hexenoic acid.
Tesamorelin peptide jẹ afọwọṣe peptide sintetiki ti iduroṣinṣin ti peptide hypothalamic, Hormone Tu silẹ Hormone (GHRH) ti tọka fun idinku ti ọra inu inu pupọ ninu awọn alaisan ti o ni kokoro-arun HIV pẹlu lipodystrophy. Lipodystrophy jẹ ipo ijẹ-ara ti a ṣe afihan nipasẹ resistance insulin, atunkọ sanra, ati hyperlipidemia ti o ni nkan ṣe pẹlu itọju ailera antiretroviral fun ikolu HIV.
Tesamorelin peptide jẹ homonu ti o da silẹ homonu idagba (GHHRH) afọwọṣe ti o ti han lati mu homonu idagba ati awọn ipele IGF-1 pọ si. Tesamorelin lọwọlọwọ jẹ homonu itusilẹ GH ti o munadoko julọ lori ọja. O jẹ peptide injectable ti o ṣe agbejade iṣelọpọ adayeba ti o tobi julọ ti HGH (Homone Growth Human). O sopọ ati ṣe iwuri awọn olugba GHRH eniyan pẹlu agbara kanna bi GHRH ti ara wa. O ko ti han lati ni ipa pataki awọn homonu pituitary miiran ninu ara.
Irorun ti o ni itara: Ẹjẹ Pituitary
Awọn anfani TESAMORELIN:
Ṣe alekun awọn iṣelọpọ adayeba ti HGH (homonu idagba eniyan)
Ṣe alekun IGF-1 (Ifosiwewe Growth Insulini – 1) laisi iyipada awọn paramita glukosi
Ti dinku triglycerides
Tissue Adipose Visceral Dinku (VAT)
Idinku Iwọn Media Intima Carotid (cIMT)
Imudara ilọsiwaju ninu awọn agbalagba ti o ju ọdun 60 lọ.
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