Gabaɗaya, haɓaka sabbin samfuran halittu dole ne su bi ta (1) binciken dakin gwaje-gwaje (binciken hanyoyin samar da kayayyaki da kafa ƙa'idodin sarrafa inganci) za su wuce gwajin aminci na samfurin da aka gwada (4) Magunguna suna buƙatar shiga cikin matakai biyar na aikin bincike, kamar gwajin gwaji na lokaci na I (gwajin lafiyar kwayoyi tare da masu sa kai masu lafiya), gwaji na asibiti na II (ƙananan Clinical). Binciken Pharmacodynamics), da gwajin gwaji na asibiti na III (babban bincike na Clinical Pharmacodynamics), kafin a amince da su don samar da gwaji. Bayan shekara guda na samar da gwaji, dole ne miyagun ƙwayoyi ya ba da rahoton sakamakon ingantaccen kwanciyar hankali da kuma ƙarin faɗaɗa gwaje-gwaje na asibiti kafin neman izinin samarwa na yau da kullun.