ANA KASANCEWA GA MAGANIN MAGANIN POLYPEPTIDE, maganin rigakafi, maganin rigakafi, peptides antimicrobial na aikin gona, peptides na abinci, kayan kwalliyar sinadarai na yau da kullun, peptides na SOYAYYA don abinci, peptides na masara, peptides na yisti, peptides na kokwamba.
Daga ra'ayi na aikin, ana iya raba shi zuwa peptide antihypertensive, peptide antioxidant, peptide mai rage cholesterol, opioid mai aiki peptide, babban F-darajar oligopeptide, peptide dandano abinci da sauransu.
Peptide mai aiki, tare da abinci mai gina jiki, hormone, hanawa enzyme, tsarin rigakafi, antibacterial, antiviral, antioxidant yana da dangantaka ta kusa. Peptides gabaɗaya an raba su zuwa: magungunan peptide da samfuran lafiyar peptide. Magungunan peptide na al'ada galibi sune hormones peptide. An samar da ci gaban magungunan peptide a fannoni daban-daban na rigakafi da magance cututtuka, musamman a fagage masu zuwa.
Anti-tumor polypeptide
Tumorigenesis shine sakamakon dalilai da yawa, amma a ƙarshe ya haɗa da ka'idar maganganun oncogene. An gano yawancin kwayoyin da ke da alaƙa da ƙari da abubuwan da suka dace a cikin 2013. Binciken peptides wanda ke ɗaure musamman ga waɗannan kwayoyin halitta da abubuwan da suka dace ya zama sabon wuri a cikin neman magungunan maganin ciwon daji. Alal misali, an yi amfani da somatostatin don magance ciwon daji na endocrin na tsarin narkewa; Masu bincike na Amurka sun sami hexapeptide wanda zai iya hana adenocarcinoma mai mahimmanci a cikin vivo; Masana kimiyya na Swiss sun gano wani octapeptide wanda ke haifar da apoptosis a cikin kwayoyin tumo.
Antiviral polypeptide
Ta hanyar ɗaure takamaiman masu karɓa akan sel masu masauki, ƙwayoyin cuta suna tallata ƙwayoyin sel kuma suna dogara da takamaiman abubuwan da suka shafi furotin don sarrafa furotin da kwafin acid nucleic. Saboda haka, peptides daure don karɓar masu karɓar salula ko wuraren aiki kamar ƙwayoyin cuta na ƙwayoyin cuta za a iya dubawa daga ɗakin karatu na peptide don maganin rigakafi. A cikin 2013, Kanada, Italiya da sauran ƙasashe sun bincikar ƙananan peptides da yawa tare da juriya na cututtuka daga ɗakin karatu na peptide, kuma wasu daga cikinsu sun shiga mataki na gwaji na asibiti. A watan Yuni na shekarar 2004, Cibiyar Nazarin Kwayoyin Halitta, Cibiyar Nazarin Kimiyya ta kasar Sin ta ba da rahoton cewa, muhimmin alkiblar aikin kirkire-kirkire na ilmi da Cibiyar Nazarin Kwayoyin Halitta, Kwalejin Kimiyya ta kasar Sin ta gudanar, "Bincike kan tsarin hada-hadar kwayar halitta ta SARS-CoV da masu hana Fusion", wanda cibiyar nazarin ilmin halitta, da kwalejin kimiyyar kasar Sin da cibiyar nazarin ilmin halittu ta zamani, da kimiyyar rayuwa, ta jami'ar Wuhan, suka gudanar, ya samu ci gaba sosai. Gwaje-gwaje sun tabbatar da cewa HR2 peptide da aka ƙera na iya hana kamuwa da ƙwayoyin ƙwayoyin cuta ta hanyar ƙwayar cuta ta SARS, kuma tasirin hanawa mai tasiri yana cikin tarin nmoles da yawa. Hakanan an sami ci gaba mai mahimmanci a cikin gwajin hana kamuwa da cuta na ƙwayoyin cuta na haɗawa da bayyana HR1 peptide da gwaje-gwajen ɗaurin in vitro na HR1 da HR2. Magungunan peptide da aka ƙera don hana haɗakar ƙwayar cuta ta SARS na iya hana kamuwa da cutar kuma, a cikin yanayin marasa lafiya, suna hana ci gaba da yaduwar cutar a cikin jiki. Maganin polypeptide yana da duka ayyuka na rigakafi da na warkewa. Masu bincike a Cibiyar Nazarin Injiniya ta Cell na Jami'ar Kiwon Lafiya ta Soja ta huɗu sun haɗa peptides tara waɗanda za su iya hanawa da kuma hana mamaye ƙwayar cutar SARS cikin sel.
Cytokines suna kama da peptides
Yin amfani da masu karɓa don sanannun cytokines don nunawa cytokine mimics daga ɗakunan karatu na peptide ya zama wurin bincike a cikin 2011. Binciken da mutane a kasashen waje erythropoietin, mutane suna haɓaka hormone platelet, hormone girma, ƙwayar jijiyoyi da kuma cewa nau'o'in ci gaba irin su interleukin - 1 simulation peptide, simulation na peptide jerin amino acid da kuma m cell factor daban-daban, jerin amino acid amma yana da aiki na cytokines, kuma yana da abũbuwan amfãni daga kanana.nauyin kwayoyin halitta. A cikin 2013 waɗannan cytokine suna kwaikwayon peptides suna ƙarƙashin bincike na musamman ko na asibiti.
Antibacterial aiki peptide
Lokacin da kwari ke motsawa ta yanayin waje, ana samar da adadi mai yawa na peptides na cationic tare da aikin ƙwayoyin cuta. A cikin 2013, fiye da nau'ikan peptides na antimicrobial fiye da 100 an gwada su. Gwaje-gwajen in vitro da in vivo sun tabbatar da cewa yawancin peptides na antimicrobial ba wai kawai suna da ƙarfin ƙwayoyin cuta da ƙwayoyin cuta ba, har ma suna iya kashe ƙwayoyin tumor.
Alurar rigakafin peptide
Alurar rigakafin peptide da allurar nucleic acid sun kasance daya daga cikin muhimman al'amura a fagen bincike na rigakafin a cikin 2013. An gudanar da bincike da yawa da haɓaka rigakafin ƙwayoyin cuta na peptide a duniya a cikin 2013. Misali, a cikin 1999, NIH ta buga littafin. Sakamakon gwaji na asibiti na nau'ikan allurar peptide na kwayar cutar HIV-I iri biyu akan batutuwan ɗan adam; An duba polypeptide daga furotin na waje na membrane E2 na cutar hanta C (HCV), wanda zai iya motsa jiki don samar da kwayoyin kariya. Amurka tana haɓaka maganin zazzabin cizon sauro polyvalent antigen polypeptide; Alurar rigakafin peptide na mutum papillomavirus don kansar mahaifa ya shiga gwaji na asibiti kashi na II. Har ila yau, kasar Sin ta yi ayyuka da yawa a cikin binciken allurar polypeptide iri-iri.
Peptides don ganewar asali
Babban amfani da peptides a cikin reagents na bincike shine azaman antigens, ƙwayoyin rigakafi don gano daidaitattun ƙwayoyin cuta. Polypeptide antigens sun fi ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙwayoyin cuta na asali ko antigens furotin na parasitic kuma suna da sauƙin shiryawa. Maganganun gano ƙwayoyin cuta waɗanda aka haɗa tare da antigens na polypeptide a cikin 2013 sun haɗa da: A, B, C, G cutar hanta, HIV, cytomegalovirus ɗan adam, ƙwayar cutar ta herpes simplex, ƙwayar cuta ta rubella, Treponema pallidum, cysticercosis, trypanosoma, cutar Lyme da masu sake gano rheumatoid. Yawancin peptide antigens da aka yi amfani da su an samo su ne daga furotin na asali na jikin kwayoyin halitta, kuma wasu sun kasance sababbin peptides da aka samu daga ɗakin karatu na peptide.
