A cikin jikin mutum, metabolism makamashi ya dogara ne akan zagayowar tricarboxylic acid, wanda ke amfani da D-glucose azaman makamashi. A cikin juyin halitta na dogon lokaci, jikin ɗan adam ya ƙirƙiri wani tsari na ƙayyadaddun tsarin halitta wanda ke ganewa da kuma daidaita ƙwayoyin glucose. Tare da inganta yanayin rayuwar mutane, ciwon sukari, "mai kisan kai", ya jefa lafiyar mutane cikin haɗari kuma ya kawo nauyi mai nauyi ga al'umma. Yawan glucose na jini akai-akai da allurar insulin suna kawo rashin jin daɗi ga marasa lafiya. Hakanan akwai yuwuwar haɗari kamar wahala wajen sarrafa adadin allura da yaduwar cututtukan jini. Sabili da haka, haɓakar biomaterials na bionic don sakin insulin mai sarrafawa mai hankali shine mafita mai kyau don cimma dogon lokaci na sarrafa matakan glucose na jini a cikin masu ciwon sukari.

Akwai nau'ikan isomers na glucose iri-iri a cikin abinci da ruwan jiki na jikin ɗan adam. Enzymes na nazarin halittu na jikin mutum na iya gane daidaitattun kwayoyin glucose kuma suna da matsayi na musamman. Koyaya, sinadarai na roba yana da takamaiman sanin ƙwayoyin glucose. Tsarin yana da matukar wahala. Wannan shi ne saboda tsarin kwayoyin halitta na kwayoyin glucose da isomers (irin su galactose, fructose, da dai sauransu) suna da kama da juna, kuma suna da rukunin aiki guda ɗaya kawai na hydroxyl, wanda ke da wuya a iya gane shi daidai da sinadarai. 'Yan sinadarai kaɗan waɗanda aka ba da rahoton suna da takamaiman ikon ganewar glucose kusan duk suna da matsaloli kamar tsarin haɗakarwa.

Kwanan nan, ƙungiyar Farfesa Yongmei Chen da Mataimakin Farfesa Wang Renqi na Jami'ar Kimiyya da Fasaha ta Shaanxi sun haɗu tare da Mataimakin Farfesa Mei Yingwu na Jami'ar Zhengzhou don tsara wani sabon nau'i bisa tsarin bidentate-β- Hydrogel na cyclodextrin. Ta hanyar gabatar da daidaitattun ƙungiyoyin phenylboronic acid guda biyu akan 2,6-dimethyl-β-cyclodextrin (DMβCD), an kafa tsaga kwayoyin halitta wanda ya dace da tsarin topological D-glucose, wanda za'a iya haɗa shi musamman tare da ƙwayoyin D-Glucose. da kuma fitar da protons, wanda hakan ya sa hydrogel ya kumbura, wanda hakan ya sa insulin ɗin da aka riga aka ɗora a cikin hydrogel ɗin da aka ɗora don fitar da sauri cikin yanayin jini. Shirye-shiryen bidentate-β-cyclodextrin kawai yana buƙatar matakai uku na amsawa, baya buƙatar yanayi mai tsanani, kuma yawan abin da aka samu yana da girma. Hydrogel da aka ɗora tare da bidentate-β-cyclodextrin da sauri yana amsa hyperglycemia kuma yana fitar da insulin a cikin nau'in berayen masu ciwon sukari na I, wanda zai iya cimma dogon lokaci na sarrafa matakan glucose na jini cikin sa'o'i 12.