ʻO Tesamorelin peptide (INN) (inoa kālepa Egrifta) he ʻano hana synthetic o ka hormone hoʻokuʻu-hormone-releasing hormone (GHRH) i hoʻohana ʻia i ka mālama ʻana i ka lipodystrophy pili i ka maʻi HIV, i ʻae ʻia i ka makahiki 2010. Hana ʻia a hoʻomohala ʻia e Theratechnologies, Inc. .o Kanada. ʻO ka lāʻau lapaʻau he peptide synthetic i loaʻa i nā 44 amino acids o ke kanaka GHRH me ka hoʻohui o kahi hui trans-3-hexenoic acid.

ʻO Tesamorelin peptide kahi mea hoʻohālikelike synthetic peptide i hoʻopaʻa ʻia o ka peptide hypothalamic, Growth Hormone Releasing Hormone (GHRH) i hōʻike ʻia no ka hōʻemi ʻana i ka momona o ka ʻōpū i nā maʻi maʻi HIV me ka lipodystrophy. ʻO ka lipodystrophy kahi maʻi metabolic i hōʻike ʻia e ka insulin resistance, ka hāʻawi hou ʻana i ka momona, a me ka hyperlipidemia e pili ana me ka antiretroviral therapy no ka maʻi HIV.

ʻO Tesamorelin peptide kahi mea hoʻohālikelike hoʻokuʻu hormone ulu (GHRH) i hōʻike ʻia e hoʻonui i ka hormone ulu a me nā pae IGF-1. ʻO Tesamorelin ka mea hoʻokuʻu GH maikaʻi loa i kēia manawa ma ka mākeke. He peptide injectable ia e hoʻoulu ai i ka hana kūlohelohe nui o HGH (Human Growth Hormone). Hoʻopaʻa a hoʻoulu i nā mea loaʻa GHRH kanaka me ka mana like me kā mākou GHRH maoli. ʻAʻole i hōʻike ʻia e pili nui i nā hormones pituitary i loko o ke kino.

Hoʻoulu ʻia ʻo Gland: Pituitary Gland

Nā pōmaikaʻi o TESAMORELIN:

Hoʻonui i nā hana kūlohelohe o HGH (hormone ulu kanaka)

Hoʻonui i ka IGF-1 (Insulin Growth Factor - 1) me ka hoʻololi ʻole i nā ʻāpana glucose

Hoʻemi ʻia nā triglycerides

Hoʻemi ʻia ʻo Visceral Adipose Tissue (VAT)

Hoʻemi ʻia ka nui o ka Carotid Intima Media (cIMT)

Hoʻonui ka cognition i nā pākeke ma luna o 60 mau makahiki.

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