Nthawi zambiri, kupanga zinthu zatsopano zamoyo kuyenera kudutsa (1) kafukufuku wa labotale (kufufuza njira zopangira ndikukhazikitsa miyezo yoyendetsera bwino) (2) Maphunziro a Preclinical (pharmacological, toxicological, pharmacodynamic ndi zoyeserera zina zanyama) (3) Chakudya chaumoyo adzapambana mayeso a chitetezo cha mankhwala oyesedwa (4) Mankhwalawa amayenera kudutsa magawo asanu a ntchito yofufuza, monga kuyesa kwachipatala kwa gawo I (kuyesa chitetezo cha mankhwala ndi anthu odzipereka athanzi), gawo lachiwiri la mayesero azachipatala (kachipatala kakang'ono). Pharmacodynamics Research), ndi gawo lachitatu la mayesero azachipatala (akuluakulu a Clinical Pharmacodynamics Research), asanavomerezedwe kuti apangidwe. Pambuyo pa chaka chimodzi choyesera, mankhwalawa ayenera kufotokoza zotsatira za kukhazikika kwabwino komanso kuwonjezereka kwa mayesero azachipatala asanapemphe chilolezo chovomerezeka.