Wnt imayendetsedwa ndi zolandilira pa cell pamwamba, zomwe zimayambitsa kuchulukira kwa zochitika mkati mwa cell. Zizindikiro zambiri kapena zochepa zimatha kukhala zowopsa, zomwe zimapangitsa kuti zikhale zovuta kuphunzira njira iyi pogwiritsa ntchito njira zomwe zimathandizira ma cell cell receptors.

Pakukula kwa embryonic, Wnt imayang'anira kukula kwa ziwalo zambiri, monga mutu, msana, ndi maso. Imasunganso ma cell tsinde mu minyewa yambiri mwa akulu: Ngakhale kusakwanira kwa Wnt kungayambitse kulephera kukonza minofu, kungayambitse chizindikiro cha Wnt chokwera mu khansa.

Zimakhala zovuta kukwaniritsa zoyenera kuchita pogwiritsa ntchito njira zokhazikika zoyendetsera njira izi, monga kukondoweza kwamankhwala. Kuti athetse vutoli, ochita kafukufuku adapanga mapuloteni ovomerezeka kuti ayankhe kuwala kwa buluu. Mwanjira imeneyi, amatha kukonza bwino mulingo wa Wnt posintha mphamvu ndi nthawi ya kuwala.

"Kuwala ngati njira yochiritsira kwagwiritsidwa ntchito mu photodynamic therapy, yomwe ili ndi ubwino wa biocompatibility ndipo palibe zotsatira zotsalira m'dera lowonekera. Komabe, mankhwala ambiri a photodynamic nthawi zambiri amagwiritsa ntchito kuwala kuti apange mankhwala amphamvu kwambiri, monga mitundu ya oxygen yogwira ntchito. kusiyanitsa pakati pa minyewa yachibadwa ndi minyewa yodwala, chithandizo chamankhwala chimakhala chosatheka," Zhang adati: "Mu ntchito yathu, tawonetsa kuti kuwala kwa buluu kumatha kuyambitsa njira zolumikizirana m'zigawo zosiyanasiyana za miluza ya achule. Tikuwona molondola kuchepetsa vuto la toxicosis yomwe ikubwera. "

Ofufuzawo adawonetsa ukadaulo wawo ndikutsimikizira kusinthika kwake komanso kukhudzidwa kwake polimbikitsa kukula kwa msana ndi mutu wa mazira a chule. Amaganiza kuti ukadaulo wawo utha kugwiritsidwanso ntchito kuzinthu zina zolandilira nembanemba zomwe zakhala zovuta kuzitsata, komanso nyama zina zomwe zimagawana njira ya Wnt, kuti zimvetsetse momwe njirazi zimayendetsera chitukuko komanso zomwe zimachitika zikatha.

"Pamene tikupitiriza kukulitsa njira yathu yowunikira kuwala kuti tipeze njira zina zowonetsera chitukuko cha embryonic, tidzapatsa gulu lachitukuko cha biology ndi zida zamtengo wapatali zomwe zingawathandize kudziwa zotsatira za zizindikiro zomwe zimachokera kuzinthu zambiri zachitukuko," adatero Yang. .

Ofufuza akuyembekezanso kuti ukadaulo wogwiritsa ntchito kuwala womwe amagwiritsa ntchito pophunzira Wnt utha kuunikira kukonza kwa minofu ndi kafukufuku wa khansa m'matenda amunthu.

"Chifukwa khansa nthawi zambiri imakhala ndi ma siginecha omwe amalowetsedwa mopitilira muyeso, timawona kuti zoyambitsa zowunikira za Wnt zitha kugwiritsidwa ntchito pofufuza momwe khansa imakulira m'maselo amoyo," adatero Zhang. "Kuphatikizana ndi kujambula kwa maselo amoyo, tidzatha kudziwa mochulukira zomwe zingasinthe maselo abwinobwino kukhala maselo a khansa. Chizindikiro cha chizindikirochi chimapereka chidziwitso chachikulu cha chitukuko cha mankhwala omwe akuwongolera mu mankhwala olondola m'tsogolomu."