Asayansi aku America adaphunzira momwe zimakhalira pakuwotcha mafuta, adazindikira puloteni yomwe imagwira ntchito yofunika kwambiri pakuwongolera kagayidwe, ndikutsimikizira kuti kuletsa ntchito yake kumatha kulimbikitsa izi mu mbewa. Puloteni yotchedwa Them1 imapangidwa m'mafuta abulauni, zomwe zimapereka njira yatsopano kwa ofufuza kuti apeze chithandizo chamankhwala chothandizira kunenepa kwambiri.
Asayansi omwe ali pa phunziro latsopanoli akhala akuphunzira Them1 kwa zaka pafupifupi khumi, ndipo ali ndi chidwi ndi momwe mbewa zimapangira mapuloteni ambiri mu minofu yawo ya bulauni ya adipose pansi pa kutentha. Mosiyana ndi minofu yoyera ya adipose yomwe imasunga mphamvu zochulukirapo m'thupi monga lipids, minofu ya bulauni imawotchedwa mwachangu ndi thupi kuti ipange kutentha tikamazizira. Pachifukwa ichi, maphunziro ambiri odana ndi kunenepa kwambiri ayang'ana zoyesayesa zosintha mafuta oyera kukhala mafuta a bulauni.
Ofufuza akuyembekeza kupanga zoyeserera kutengera maphunziro oyambilira a mbewa momwe makoswe amasinthidwa kuti akhale opanda Them1. Chifukwa ankaganiza kuti Them1 ikuthandiza mbewa kutulutsa kutentha, ankayembekezera kuti kuzichotsa kungachepetse mphamvu zawo. Koma zikuoneka kuti M'malo mwake, mbewa kusowa mapuloteni kudya kwambiri mphamvu kupanga zopatsa mphamvu, kotero kuti kwenikweni kawiri kuposa mbewa yachibadwa, koma kuonda.
Komabe, mukachotsa jini ya Them1, mbewa imatulutsa kutentha kwambiri, osati zochepa.
M’kafukufuku wongofalitsidwa kumene, asayansi afufuza mozama pazifukwa za chochitika chosayembekezeka chimenechi. Izi zimaphatikizapo kuyang'ana momwe Them1 imakhudzira ma cell amafuta a bulauni omwe amamera mu labotale pogwiritsa ntchito ma microscopes opepuka komanso ma elekitironi. Izi zikuwonetsa kuti mafuta akayamba kuyaka, mamolekyu a Them1 amasinthidwa ndi mankhwala, zomwe zimapangitsa kuti azifalikira muselo lonse.
Chimodzi mwazotsatira za kufalikira kumeneku ndikuti mitochondria, yomwe imadziwika kuti cell dynamics, imatha kusintha kusungirako mafuta kukhala mphamvu. Kukondoweza kwamafuta kukasiya, mapuloteni a Them1 amakonzanso mwachangu kukhala pakati pa mitochondria ndi mafuta, ndikuchepetsanso kupanga mphamvu.
Zithunzi zowoneka bwino kwambiri zikuwonetsa: Mapuloteni a Them1 amagwira ntchito mu minofu ya bulauni ya adipose, yopangidwa mwadongosolo lomwe limalepheretsa kuyaka kwamphamvu.
Kafukufukuyu akufotokoza njira yatsopano yomwe imayendetsa metabolism. Them1 imawononga payipi yamagetsi ndikudula mafuta opita ku mitochondria yoyaka mphamvu. Anthu alinso ndi mafuta a bulauni, omwe amapangira Them1 ochulukirapo pakazizira, kotero zomwe zapezazi zitha kukhala ndi tanthauzo losangalatsa pochiza kunenepa kwambiri.
