IMAKAMAKA imagawidwa mu mankhwala a MEDICAL POLYPEPTIDE, ma peptide antibiotics, katemera, ma peptides oletsa tizilombo toyambitsa matenda, ma peptides odyetsa, zodzoladzola za tsiku ndi tsiku za mankhwala, ma peptide a SOYBEAN a chakudya, ma peptides a corn, peptides ya yisiti, ma peptide a nkhaka zam'nyanja.
Kuchokera pamawonedwe ogwirira ntchito, imatha kugawidwa kukhala peptide yoletsa kuthamanga kwa magazi, peptide ya antioxidant, peptide yotsitsa mafuta m'thupi, opioid yogwira peptide, oligopeptide yamtengo wapatali wa F, peptide ya kukoma kwa chakudya ndi zina zotero.
Peptide yogwira, yokhala ndi zakudya, mahomoni, kuletsa kwa enzyme, kuwongolera chitetezo chathupi, antibacterial, antiviral, antioxidant ali ndi ubale wapamtima kwambiri. Ma peptides nthawi zambiri amagawidwa kukhala: mankhwala a peptide ndi mankhwala azaumoyo a peptide. Mankhwala amtundu wa peptide makamaka ndi mahomoni a peptide. Kupanga mankhwala a peptide kwapangidwa m'njira zosiyanasiyana zopewera ndi kuwongolera matenda, makamaka m'magawo otsatirawa.
Anti-chotupa polypeptide
Tumorigenesis ndi zotsatira za zinthu zambiri, koma pamapeto pake zimaphatikizapo kuwongolera mawu a oncogene. Ma jini ambiri okhudzana ndi zotupa ndi zowongolera zapezeka mu 2013. Kuwunika ma peptides omwe amamangiriza makamaka ku majini awa ndi zinthu zowongolera zakhala malo atsopano pofufuza mankhwala oletsa khansa. Mwachitsanzo, somatostatin yakhala ikugwiritsidwa ntchito pochiza zotupa za endocrine zam'mimba; Ofufuza a ku America adapeza hexapeptide yomwe imatha kuletsa kwambiri adenocarcinoma mu vivo; Asayansi aku Swiss apeza octapeptide yomwe imapangitsa apoptosis m'maselo otupa.
Antiviral polypeptide
Pomanga ma receptor apadera pama cell omwe amalandila, ma virus amatchinjiriza ma cell ndikudalira ma protease awoawo kuti apange mapuloteni komanso kugawanika kwa nucleic acid. Chifukwa chake, ma peptides omwe amamangiriza ku ma cell receptors kapena malo omwe akugwira ntchito monga ma virus proteases amatha kuyang'aniridwa kuchokera ku laibulale ya peptide kuti alandire chithandizo chamankhwala. Mu 2013, Canada, Italy ndi mayiko ena adawunika ma peptide ang'onoang'ono ambiri omwe ali ndi vuto lokana matenda kuchokera ku library ya peptide, ndipo ena alowa m'mayesero azachipatala. Mu June 2004, Institute of Microbiology, Chinese Academy of Sciences inanena kuti malangizo ofunikira a chidziwitso chatsopano chopangidwa ndi Institute of Microbiology, Chinese Academy of Sciences, "Kafukufuku pa makina a SARS-CoV cell fusion ndi Fusion inhibitors", zomwe zidapangidwa limodzi ndi Institute of Microbiology, Chinese Academy of Sciences ndi Center for Modern Virology, Life Sciences, Wuhan University, zidapita patsogolo kwambiri. Zoyeserera zatsimikizira kuti peptide yopangidwa ya HR2 imatha kuletsa bwino kufalikira kwa ma cell otukuka ndi kachilombo ka SARS, ndipo kuletsa kogwira mtima kumakhala pagulu la ma nmoles angapo. Kupita patsogolo kofunikira kwachitikanso pakuyesa kwa ma virus inhibition kuyesa kopangidwa ndi kufotokozedwa kwa HR1 peptide komanso kuyesa kwa in vitro binding kwa HR1 ndi HR2. Mankhwala a peptide opangidwa kuti aletse kuphatikizika kwa kachilombo ka SARS amatha kupewa kufalikira kwa kachilomboka ndipo, ngati ali ndi kachilomboka, amalepheretsa kufalikira kwa kachilomboka mthupi. Mankhwala a polypeptide ali ndi ntchito zodzitetezera komanso zochizira. Ofufuza ku Cell Engineering Research Center ya Fourth Military Medical University apanga ma peptide asanu ndi anayi omwe amatha kuteteza ndikuletsa kulowetsedwa kwa kachilombo ka SARS m'maselo.
Ma cytokines amatsanzira ma peptides
Kugwiritsiridwa ntchito kwa zolandilira kwa ma cytokines odziwika kuti awonetsere ma cytokine amatsanzira kuchokera ku malaibulale a peptide kwakhala malo opangira kafukufuku mu 2011. Kuwunika ndi anthu kunja kwa erythropoietin, anthu amalimbitsa mahomoni a platelet, hormone ya kukula, kukula kwa mitsempha ndi kuti zinthu zosiyanasiyana za kukula monga interleukin - 1 peptide yofananira, kayesedwe ka peptide amino acid motsatizana ndi cell factor yake yofananira ndi yosiyana, kutsatizana kwa ma amino acid koma imakhala ndi ntchito ya ma cytokines, ndipo ili ndi maubwino ang'onoang'ono.kulemera kwa maselo. Mu 2013 ma peptides otsanzira a cytokinewa ali pansi pa kufufuza kwachipatala kapena kuchipatala.
Antibacterial yogwira peptide
Tizilombo tikalimbikitsidwa ndi chilengedwe chakunja, ma peptide ambiri a cationic okhala ndi antibacterial amapangidwa. Mu 2013, mitundu yopitilira 100 ya ma peptides antimicrobial adawunikidwa. Kuyesa kwa in vitro ndi mu vivo kwatsimikizira kuti ma peptide ambiri oletsa tizilombo toyambitsa matenda sangokhala ndi mphamvu zolimbana ndi bakiteriya komanso bactericidal, komanso amatha kupha maselo otupa.
Katemera wa Peptide
Katemera wa peptide ndi katemera wa nucleic acid anali chimodzi mwazinthu zofunika kwambiri pa kafukufuku wa katemera mu 2013. Kafukufuku wambiri ndi chitukuko cha katemera wa tizilombo toyambitsa matenda adachitika padziko lonse mu 2013. Mwachitsanzo, mu 1999, NIH inafalitsa zotsatira zachipatala za mitundu iwiri ya katemera wa HIV-I virus peptide pa nkhani za anthu; Polypeptide idawunikidwa kuchokera ku membrane yakunja ya protein E2 ya kachilombo ka hepatitis C (HCV), yomwe imatha kulimbikitsa thupi kupanga ma antibodies. United States ikupanga katemera wa malungo polyvalent antigen polypeptide; Katemera wa papillomavirus peptide wa munthu wa khansa ya pachibelekero walowa m'mayesero achipatala a gawo lachiwiri. China yachitanso ntchito zambiri pakufufuza kwa mitundu yosiyanasiyana ya katemera wa polypeptide.
Peptides kuti azindikire
Waukulu ntchito peptides mu matenda reagents ndi monga ma antigen, ma antibodies kudziwa lolingana tizilombo zamoyo. Ma antigen a polypeptide ndi achindunji kwambiri kuposa ma antigen achilengedwe kapena ma parasitic protein ndipo ndi osavuta kukonzekera. Ma antibodies omwe amasonkhanitsidwa ndi ma antigen a polypeptide mu 2013 akuphatikizapo: A, B, C, G kachilombo kachiwindi, HIV, cytomegalovirus yaumunthu, herpes simplex virus, rubella virus, Treponema pallidum, cysticercosis, trypanosoma, matenda a Lyme ndi rheumatoid reagents. Ma antigen ambiri a peptide omwe amagwiritsidwa ntchito adatengedwa kuchokera ku mapuloteni amtundu wofananira, ndipo ena anali ma peptide atsopano omwe adatengedwa ku laibulale ya peptide.
