M'thupi la munthu, mphamvu ya kagayidwe kazakudya makamaka imadalira kuzungulira kwa tricarboxylic acid, komwe kumagwiritsa ntchito shuga wa D ngati chinthu champhamvu. Pachisinthiko cha nthawi yayitali, thupi la munthu limapanga dongosolo lachilengedwe komanso lachilengedwe lomwe limazindikira ndikusintha mamolekyu a glucose. Ndi kuwongolera kwa moyo wa anthu, matenda a shuga, "wakupha mwakachetechete", ayika thanzi la anthu pachiwopsezo ndikubweretsa mavuto azachuma kwa anthu. Kuchuluka kwa shuga m'magazi ndi jakisoni wa insulin kumabweretsa kusapeza bwino kwa odwala. Palinso zoopsa zomwe zingatheke monga kuvutika kuwongolera mlingo wa jakisoni ndi kufalikira kwa matenda a magazi. Chifukwa chake, kupanga ma bionic biomatadium kuti atulutse insulin yoyendetsedwa mwanzeru ndi njira yabwino yothetsera kuwongolera kwanthawi yayitali kwa glycemia mwa odwala matenda ashuga.

Pali mitundu yambiri ya ma isomers a glucose m'zakudya ndi madzi am'thupi la munthu. Ma enzymes am'thupi la munthu amatha kuzindikira mamolekyu a glucose molondola komanso kukhala ndi mawonekedwe apadera. Komabe, chemistry yopangira imazindikira mwachindunji mamolekyu a glucose. Mapangidwewo ndi ovuta kwambiri. Izi ndichifukwa choti mamolekyu a mamolekyu a glucose ndi ma isomers ake (monga galactose, fructose, etc.) ndi ofanana kwambiri, ndipo ali ndi gulu limodzi lokha la hydroxyl, lomwe ndizovuta kudziwika bwino ndi mankhwala. Ma ligand ochepa amankhwala omwe amanenedwa kuti ali ndi mphamvu yozindikira glucose pafupifupi onse amakhala ndi zovuta monga zovuta za kaphatikizidwe.

Posachedwapa, gulu la Pulofesa Yongmei Chen ndi Pulofesa Wothandizira Wang Renqi wa Shaanxi University of Science and Technology adagwirizana ndi Wothandizira Pulofesa Mei Yingwu wa Zhengzhou University kuti apange mtundu watsopano wozikidwa pa bidentate-β- Hydrogel system ya cyclodextrin. Mwa kufotokoza bwino magulu awiri a phenylboronic acid pa 2,6-dimethyl-β-cyclodextrin (DMβCD), kagawo kakang'ono kamene kamagwirizana ndi mapangidwe a D-glucose amapangidwa, omwe amatha kuphatikizidwa makamaka ndi mamolekyu a D-Glucose. ndikutulutsa ma protoni, kupangitsa kuti hydrogel kutupa, zomwe zimapangitsa kuti insulin yodzaza mu hydrogel itulutsidwe mwachangu m'magazi. Kukonzekera kwa bidentate-β-cyclodextrin kumangofunika njira zitatu zochitira, sikufuna kuti zikhale zovuta kwambiri, ndipo zokolola zake zimakhala zazikulu. Hydrogel yodzaza ndi bidentate-β-cyclodextrin imayankha mwachangu ku hyperglycemia ndipo imatulutsa insulini mumtundu wa mbewa za matenda a shuga, omwe amatha kukwaniritsa kuwongolera kwanthawi yayitali kwa shuga m'magazi mkati mwa maola 12.