Tesamorelin peptide (INN) (dzina la malonda Egrifta) ndi njira yopangira kukula kwa hormone-releasing hormone (GHRH) yomwe imagwiritsidwa ntchito pochiza lipodystrophy yokhudzana ndi HIV, yovomerezeka poyamba mu 2010. Imapangidwa ndikupangidwa ndi Theratechnologies, Inc. waku Canada. Mankhwalawa ndi peptide yopangidwa yokhala ndi ma amino acid onse 44 a GHRH yamunthu ndikuwonjezera gulu la trans-3-hexenoic acid.

Tesamorelin peptide ndi analogue yokhazikika ya peptide ya hypothalamic peptide, Growth Hormone Releasing Hormone (GHRH) yosonyezedwa pofuna kuchepetsa mafuta ochulukirapo a m'mimba mwa odwala omwe ali ndi kachilombo ka HIV omwe ali ndi lipodystrophy. Lipodystrophy ndi vuto la kagayidwe kachakudya lomwe limadziwika ndi kukana insulini, kugawanikanso kwamafuta, komanso hyperlipidemia yolumikizidwa ndi ma antiretroviral therapy ya kachilombo ka HIV.

Tesamorelin peptide ndi kukula kwa hormone-release hormone (GHRH) analog yomwe yasonyezedwa kuti iwonjezere kukula kwa hormone ndi IGF-1. Tesamorelin pakali pano ndi GH yothandiza kwambiri yotulutsa hormone pamsika. Ndi peptide yojambulidwa yomwe imapanga kupanga kwakukulu kwachilengedwe kwa HGH (Human Growth Hormone). Zimamanga ndi kulimbikitsa zolandilira za GHRH zaumunthu zomwe zili ndi mphamvu yofanana ndi GHRH yathu yachilengedwe. Sizinawonetsedwe kuti zimakhudza kwambiri mahomoni ena a pituitary m'thupi.

Kukondoweza kwa gland: Pituitary Gland

UPHINDO WA TESAMORELIN:

Kuchulukitsa kupanga kwachilengedwe kwa HGH (mahomoni akukula kwaumunthu)

Kuchulukitsa IGF-1 (Insulin Growth Factor - 1) popanda kusintha magawo a shuga

Kuchepetsa triglycerides

Kuchepetsedwa kwa Visceral Adipose Tissue (VAT)

Kuchepetsa Carotid Intima Media Size (cIMT)

Kuzindikira bwino kwa akulu opitilira zaka 60.

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