3D bioprinting nubuhanga buhanitse bwo gukora bushobora kubyara imiterere yihariye yimiterere nuburyo butandukanye muburyo butandukanye bwingirabuzimafatizo, bityo iyi gahunda ikaba ishobora kwerekana imiterere karemano yimiterere yimitsi yamaraso. Urukurikirane rwa hydrogel bio-inks yatangijwe kugirango dushushanye izo nyubako; icyakora, bio-wino iboneka ishobora kwigana imiterere yimiyoboro yamaraso isanzwe ifite aho igarukira. Muri iki gihe bio-wino ibura icapiro ryinshi kandi ntishobora kubitsa ingirabuzimafatizo zifite imbaraga nyinshi muburyo bwa 3D, bityo bikagabanya imikorere yabyo.

Kugira ngo tuneshe izo nenge, Gaharwar na Jain bakoze bio-wino nshya yakozwe na nano kugirango icapwe 3D, anatomique yuzuye imiyoboro y'amaraso. Uburyo bwabo butanga uburyo bunoze bwo gukemura kuri macrostructures na microstructures ya tissue-urwego, kuri ubu ntibishoboka hamwe na bio-wino.

Ikintu cyihariye kiranga iyi bio-wino ikorwa na nano ni uko hatitawe ku bucucike bwakagari, bugaragaza ko bwanditse cyane ndetse nubushobozi bwo kurinda selile zifunze imbaraga zogosha cyane mugihe cya bioprinting. Birakwiye ko tumenya ko 3D bio Ingirabuzimafatizo zacapwe zigumana fenotipi nzima kandi zigakomeza kubaho hafi ukwezi nyuma yo gukora.

Ukoresheje ibyo biranga bidasanzwe, bio-wino ikozwe na nano icapwa mumitsi yamaraso ya silindrike ya 3D, igizwe numuco ubana utugingo ngengabuzima twa endoteliyale na selile yimitsi itwara imitsi, biha abashakashatsi amahirwe yo kwigana ingaruka zimitsi yamaraso kandi indwara.

Iyi kontineri ya bioprint ya 3D itanga igikoresho gishoboka cyo gusobanukirwa na patrophysiologie yindwara zifata imitsi no gusuzuma imiti, uburozi cyangwa indi miti mugihe cyibigeragezo.