Wnt ikoreshwa na reseptors hejuru yakagari, itera caskade yimikorere muri selire. Ibimenyetso byinshi cyangwa bike cyane birashobora kuba ibyago, bigatuma bigora cyane kwiga iyi nzira ukoresheje tekiniki zisanzwe zitera ingirabuzimafatizo.
Mugihe cyo gukura kwa emboro, Wnt igenga iterambere ryingingo nyinshi, nkumutwe, uruti rwumugongo, namaso. Ikomeza kandi ingirabuzimafatizo mu ngingo nyinshi ku bantu bakuru: Nubwo ibimenyetso bya Wnt bidahagije bishobora gutera kunanirwa gusana ingirabuzimafatizo, bishobora gutuma ibimenyetso bya Wnt byiyongera muri kanseri.
Biragoye kugera kuburinganire bukenewe binyuze muburyo busanzwe bwo kugenzura izi nzira, nko gukurura imiti. Kugira ngo iki kibazo gikemuke, abashakashatsi bakoze protein ya reseptor kugirango basubize urumuri rwubururu. Muri ubu buryo, barashobora guhuza neza urwego rwa Wnt muguhindura ubukana nigihe cyumucyo.
"Umucyo nk'ingamba zo kuvura wakoreshejwe mu kuvura Photodynamic, ufite ibyiza byo guhuza ibinyabuzima kandi nta ngaruka zisigara mu gace kagaragaye. Icyakora, uburyo bwinshi bwo kuvura amafoto bukoresha urumuri kugira ngo butange imiti itanga ingufu nyinshi, nk'ubwoko bwa ogisijeni ikora. Nta gutandukanya ingirangingo zisanzwe hamwe nuduce twarwaye, kuvura intego ntibishoboka ", Zhang yagize ati:" Mu kazi kacu, twerekanye ko urumuri rwubururu rushobora gukora inzira zerekana ibimenyetso mu bice bitandukanye by’udusoro tw’ibikeri. Turatekereza neza Kubyutsa imbaraga zikoreshwa mu ngirabuzimafatizo zirashobora kugabanya ikibazo cy’uburozi butemewe. "
Abashakashatsi berekanye ikoranabuhanga ryabo kandi bagenzura niba rihinduka kandi bakumva ko batezimbere iterambere ry’umugongo n’umutwe w’insoro. Bavuze ko ikoranabuhanga ryabo rishobora no gukoreshwa ku zindi reseptors zifitanye isano na membrane byagaragaye ko bigoye kwibasirwa, kimwe n’andi matungo asangiye inzira ya Wnt, kugira ngo yumve neza uburyo izo nzira zigenga iterambere n’ibigenda iyo birangiye.
Yang yagize ati: "Nidukomeza kwagura sisitemu yacu yorohereza urumuri kugira ngo tumenye izindi nzira z’ibanze zerekana iterambere ry’intangangore, tuzaha umuryango w’ibinyabuzima iterambere ry’ibinyabuzima hamwe n’ibikoresho by’ingirakamaro bishobora kubafasha kumenya ibisubizo by’ibimenyetso byihishe inyuma y’iterambere ryinshi." .
Abashakashatsi kandi bizeye ko ikoranabuhanga rishingiye ku mucyo bakoresha mu kwiga Wnt rishobora kumurika gusana ingirabuzimafatizo n'ubushakashatsi bwa kanseri mu ngingo z'umuntu.
Zhang yagize ati: "Kubera ko ubusanzwe kanseri ikubiyemo ibimenyetso birenze urugero, turatekereza ko abakora Wnt bumva urumuri bashobora gukoreshwa mu kwiga iterambere rya kanseri mu ngirabuzimafatizo." "Dufatanije no gufata amashusho ya selile nzima, tuzashobora kumenya umubare ushobora guhindura ingirabuzimafatizo zisanzwe mu ngirabuzimafatizo za kanseri. Urutonde rw'ibimenyetso rutanga amakuru y'ingenzi agamije iterambere ry’imiti yihariye mu buvuzi bwuzuye mu gihe kiri imbere."
