Nigute peptide ikora? Kuki ukeneye peptide?

 KNOWLEDGE    |      2023-03-28

Kuberako duhereye kubitekerezo bya poroteyine, buri selile yo mumubiri nibintu byose byingenzi bifite proteyine zirimo. Poroteyine zingana na 16% ~ 20% byuburemere bwumubiri wumuntu. Hariho ubwoko bwinshi bwa poroteyine mumubiri wumuntu, hamwe nibintu bitandukanye nibikorwa, ariko byose bigizwe nubwoko 20 bwa acide Amino muburyo butandukanye, kandi bigahora bihindagurika kandi bigahinduka mumubiri.

Iyi aside 20 amine mumubiri wumuntu irashobora guhurizwa mubuntu muri peptide 2.020, numubare munini cyane. Ukurikije ibitekerezo byibanze ko imiterere yibinyabuzima igena imikorere, ihame ryibikorwa bya buri peptide ikora iragoye cyane. Nka antibacterial anti-inflammatory peptide, peptide yubudahangarwa bw'umubiri muri thymosine.


Antibacterial anti-inflammatory peptide: peptide ya antibacterial anti-inflammatory peptide (C-L) charge kwishyurwa neza → ibikorwa bya bagiteri selile membrane → muri patogene (nka Escherichia coli) ingirabuzimafatizo ya selile → kumeneka kw'imitsi → urupfu rwa bagiteri, ni ukuvuga kwica bagiteri; Mugihe kimwe, irashobora gutesha endotoxine → kugabanya gucanwa guterwa na LPS.

Thymosine muri peptide ikingira indwara irashobora kongera imikorere yubudahangarwa itera iterambere no gukura kwa T lymphocyte T, kongera ubushobozi bwa fagocytose ya macrophage no kongera urwego rwa interleukin. Inyana thymosine, nkuko dukunze kuyita, ikora cyane kuri sisitemu ya T-lymphocyte kugirango yongere imikorere yumubiri wa selile yumubiri kandi yongere imbaraga zo kurwanya indwara.

Il-6 ni ibintu bya pleiotropique, bishobora kugenga imikurire n’itandukanyirizo ry’utugingo ngengabuzima dutandukanye, bikagenga uburyo bwo kwirinda indwara, igisubizo gikaze ndetse n’imikorere ya hematopoietic, kandi bikagira uruhare runini mu kurwanya umubiri kwirinda indwara.


LTA irashobora kongera imikorere yubudahangarwa muguhuza TLR4 / MD2 complex → gukora ya NF-kB yerekana inzira → ibikorwa bya fagocytose ya ↑ T lymphocytes na macrophage nibintu byubudahangarwa (nka TNF-α, IL-6, IL-1β, nibindi).

Imiterere itandukanye ya physiologique yabantu ntabwo ari imwe, bizatera ingaruka zo gufata peptide ntabwo ari kimwe, nko kurya ifunguro rimwe abantu bamwe barya ibinure byinshi, abantu bamwe ntibarya ibinure.


Ukurikije imyaka, ingaruka zabasaza mubisanzwe ziruta abakiri bato; Duhereye ku buzima, abantu barwaye barya peptide. Umuntu muzima. Ku bijyanye n'umunaniro, abantu bananiwe bakora neza kurusha abandi; Abantu babazwe bakoze neza na peptide kurusha abantu batabazwe ...


Kubera ko peptide ifite agaciro kintungamubiri nyinshi, byoroshye kuyikuramo, kugabanya umutwaro wurugendo rwigifu, guteza imbere gukira ibikomere no kurwanya umunaniro, bityo rero ni kimwe nubuvuzi bukwiye, mugihe abantu bari mumiterere yumubiri, bakeneye peptide zitandukanye. imirimo yo kuzuzanya.

Hamwe niterambere ryumuryango, abantu ba kijyambere bahura nibibazo byinshi bijyanye no kugabanya peptide. Kurugero, ifumbire mvaruganda nudukoko twangiza udukoko twangiza imisemburo yangiza proteyine mubiryo kandi ikagabanya imisemburo ya exogenous. Ibidukikije bigezweho kubera ihumana ry’ikirere, amazi n’ubutaka bwanduye, gutakaza cyangwa kudakora imisemburo mu mubiri w’umuntu, ubushobozi bwumubiri wumuntu bwo kwangiza poroteyine buracika intege, igogora no kwangirika ntibishobora gukorwa mubisanzwe, amahirwe yo kubona peptide ni yagabanutse, bityo umubiri wumuntu ukabura peptide; Imirasire ya kijyambere itera imikorere yumubiri wumuntu kuba muke, ubushobozi bwo gusya no gutesha agaciro poroteyine birabujijwe, sisitemu yo kwinjiza ntishobora kwinjiza poroteyine bisanzwe, kandi amahirwe yo kubona peptide aragabanuka.


Kubura peptide byabaye ikibazo rusange kubera kwangirika kwinshi no gutakaza peptide mumubiri wumuntu. Iyo ubushobozi bwumubiri wumuntu bwoguhindura peptide bugabanutse cyane, umubiri wumuntu ntushobora kuzuza peptide mugihe, bityo rero birakenewe gufata ibiyobyabwenge kugirango umubiri wumuntu ukeneye.