Intangiriro kuri MGF:

Imikurire ya Mechano Ikura rya Mechano, ikunze kwitwa MGF, ni igabanywa rya IGF-1, ikintu cyo gukura / ikintu cyo gukura gikomoka kumyitozo ngororangingo cyangwa imitsi yangiritse, Bituma bigorana kumenya izindi mpinduka za IGF.

Igituma MGF idasanzwe ninshingano zayo zidasanzwe mu mikurire yimitsi. MGF ifite ubushobozi budasanzwe bwo gutera imikurire yimyanda no gutera imbere mugukoresha ingirangingo z'imitsi no kongera kugenzura intungamubiri za poroteyine. Ubu bushobozi budasanzwe butezimbere byihuse kandi byihuta gukura kwimitsi. Usibye indangarubuga ya IGF-1, MGF itangiza kandi imitsi ya selile (stem selile) ingirabuzimafatizo, bityo ikongerera intungamubiri za poroteyine; Kubwibyo, iyo ikoreshejwe neza, irashobora kunoza cyane imitsi.

IGF-1 ni imisemburo ya aside-amino 70-ifite imiterere isa na insuline isohoka mu mwijima, kandi IGF-1 isohoka iterwa no gusohora no kurekura imisemburo ikura (GH) mu mubiri. IGF-1 yibasira ingirabuzimafatizo hafi ya zose mu mubiri, cyane cyane ko igira uruhare mu gusana selile. Iyo imitsi yangiritse, ibi bitera reaction mumubiri witwa T.

IGF-1 igizwe mubice bibiri, IGF-1Ec na IGF-1Ea, iyambere yari MGF.

MGF itera ibice bibiri bya IGF byakozwe numwijima:

Iya mbere ni IGF-1EC: iyi niyo ntambwe yambere yo kurekura igf splicing variant, kandi izabikora

Ikangura ibikorwa bya selile

Iya kabiri ni hepatike IGF-IEA: Iyi ni irekurwa rya kabiri igf iva mu mwijima, kandi inyungu zayo za anabolike ni nto cyane kuruta izambere.

MGF itandukanye na variant ya kabiri, IGF-IEa, kubera ko ifite urutonde rwa peptide itandukanye kandi ishinzwe kuzuza ingirabuzimafatizo mu mitsi ya skeletale; Muyandi magambo, itanga inyungu nyinshi za anabolike ningaruka ndende kuruta sisitemu ya kabiri ya MGF y'umwijima.

Ugomba rero gutekereza kuri MGF nkibintu byongerewe imbaraga bya igf ukurikije inyungu za anabolike. Nyuma yimyitozo, gene ya IGF-I itera MGF hanyuma igatera hypertrophyie no gusana ibyangiritse byimitsi ikoresheje ingirabuzimafatizo zumye hamwe nizindi nzira zikomeye za anabolike (harimo na synthesis ya proteine ​​yasobanuwe haruguru) no kongera azote mu mitsi.

Imbeba, ubushakashatsi bumwe bwerekanye ubwiyongere bwa 20% mumitsi hamwe no gutera inshinge imwe ya MGF, ariko ndatekereza ko inyinshi murubwo bushakashatsi atari zo, ariko ubushobozi bwa MGF ntawahakana.

Gutera kwa MGF gukora ingirabuzimafatizo, biganisha ku mikurire yimitsi mishya mumubiri. Mubyongeyeho, kuba MGF ihari byongera proteine ​​ya proteine ​​yumubiri, bityo bigatera myohypertrophy no kwaguka! Kura! Kura! Nibyo, ni ngombwa cyane gusana 196 iriho

Nibyo, ibintu byo kugarura bifitanye isano na MGF ntagushidikanya ni ahantu heza cyane kuri MGF.

Mugihe imikorere ya MGF ishobora gusa nkaho iteye urujijo ukireba, inzira ubwayo iba yoroshye rwose iyo urebye intambwe ku yindi:

1.IGF-1 irekurwa nimyitozo ngororamubiri (ibaho nyuma yimyitozo)

2. Gabanya IGF-1 na MGF

3.MGF itangiza kugarura ingirangingo z'imitsi nyuma yo kwangirika kwimyitozo ngororamubiri ikora ingirabuzimafatizo

Ikoreshwa rya MGF

Bigenda bite imitsi yawe iyo witoza? Birasenyuka, selile zangiritse, ingirangingo z'imitsi zigomba gusanwa, kandi umubiri wawe utanga uburyo bubiri bwa MGF butandukanye. Isohora ryambere ryumwijima 1 variant hejuru byorohereza imitsi gukira. Byagenda bite niba MGF idahari? Mu buryo bworoshye, ingirangingo z'imitsi ntizisana kandi zipfa. Ingirabuzimafatizo ni ingirabuzimafatizo zikuze zidashobora kugabana, ingirabuzimafatizo zikomoka mu ngirabuzimafatizo zigabanyijemo ingirabuzimafatizo binyuze muri mitito, bityo umubiri ntushobora gusana ingirabuzimafatizo binyuze mu gusimbuza ingirabuzimafatizo nyuma yo kwangirika kw'imitsi, irashobora gusana gusa ingirabuzimafatizo z'umwimerere, niba selile ntizisanwa, bazapfa. Imitsi yawe izagenda iba nton'intege nke. Ukoresheje MGF, gukira kwumubiri birashobora kwihuta kandi ingirangingo z'imitsi zirashobora kwiyongera mugukangura gukura kwingirabuzimafatizo. Kubijyanye na dose, 200mcg gutera inshinge zombi guhitamo neza (gutera inshinge birakenewe kuri MGF). Ikibazo gusa na MGF nuko igice cyacyo cya kabiri ari gito cyane, iminota 5-7 gusa, kandi igomba guhita ikoreshwa nyuma yimyitozo kugirango ibone ibisubizo byiza, mugihe abantu benshi badafite umwanya wo kuyikoresha muriyi idirishya nyuma y'amahugurwa.

PEG-MGF ni iki?

Nkuko byavuzwe haruguru, inenge nini ya MGF nigihe gito cyibikorwa byayo, bityo verisiyo ndende ya MGF, PEG MGF, yarakozwe. Wongeyeho PEG (polyethylene glycol, inyongeramusaruro idafite uburozi) muri MGF, igice cya kabiri cyubuzima bwa MGF gishobora kwiyongera kuva muminota kugeza kumasaha. Igihe kinini cyibikorwa bivuze ko akamaro kacyo hamwe nuburyo bwinshi bizatera imbere cyane, kandi PEG MGF igira ingaruka zifatika aho imitsi yangiritse cyangwa irwaye, aho kugarukira kumurongo umwe.

Nigute nkoresha PEG-MGF

Agace gakurikira dukeneye kwibandaho nuburyo bwo kubona byinshi muri verisiyo ndende ya MGF. Iyo imitsi yawe yangiritse, umubiri wawe urekura impiswi ya MGF clip-on variant yasobanuwe haruguru, igakurikirwa nuburyo bukora kuva mwumwijima bifite inyungu nke za anabolike. Birasa nkaho ari imyanda yo gutera MGF muri iki gihe, kuko urimo ugabanya intege nke z'umubiri wenyine, ntukongere. Kubwibyo, gukoresha PEG MGF muminsi idakora imyitozo ninzira nziza. Kubera kwangirika kwimitsi, MGF ifite reseptor nyinshi, kandi ingaruka zayo ni gahunda. Mugukomeza kugumana azote, guhinduranya poroteyine no gukora selile ikora, bizafasha kugarura imitsi yose. Mugukora utyo, uba wongereye igihe bisaba umubiri gusana imitsi hamwe nuburyo bwo gukura. Gukoresha PEG MGF ifatanije na IGF biratunganye, ariko kubera reseptor ikomeye ya IGF, niba ukoresheje IGF-1 na PEG MGF byombi, imikorere ya MGF izagabanuka.

Ibyifuzo byanjye nibi bikurikira:

IGF DES cyangwa IGF1-LR3 ikoreshwa muminsi yimyitozo mbere yimyitozo, itabuza MGF kurekura umwijima wumubiri. IGF-DES yakoreshejwe mugutezimbere byihuse urubuga rwatinze, hanyuma MGF ya 200-400 MCG yakoreshejwe bukeye kugirango yongere uburyo bwo gukira no gukura. Gukorana neza.

Ububiko bwa PEG MGF

MGF irashobora kubikwa muri firigo mugihe cyamezi atandatu. Irinde guhura n'ubushyuhe cyangwa izuba

Munsi y'umucyo.