Mu mubiri w'umuntu, metabolism y'ingufu ahanini ishingiye kuri cycle ya tricarboxylic, ikoresha D-glucose nk'ingufu. Mu bwihindurize bw'igihe kirekire, umubiri w'umuntu wakoze sisitemu ihambaye kandi yihariye y'ibinyabuzima imenya no guhinduranya molekile ya glucose. Iterambere ry’imibereho y’abantu, diyabete, "umwicanyi ucecetse", yahungabanije cyane ubuzima bw’abantu kandi izana umutwaro uremereye mu bukungu muri sosiyete. Amaraso ya glucose kenshi hamwe ninshinge za insuline bizana abarwayi. Hariho n'ingaruka zishobora kubaho nko kugora kugenzura igipimo cyo gutera inshinge no gukwirakwiza indwara zamaraso. Kubwibyo, iterambere rya bionic biomaterial kugirango irekure ubwenge bwa insuline igenzurwa nubwenge nigisubizo cyiza cyo kugera ku kugenzura igihe kirekire urugero rwamaraso ya glucose kubarwayi ba diyabete.

Hariho ubwoko bwinshi bwa glucose isomers haba mubiryo ndetse namazi yumubiri wumubiri wumuntu. Imisemburo ya biologiya yumubiri wumuntu irashobora kumenya neza molekile ya glucose kandi ifite urwego rwo hejuru rwihariye. Nyamara, chimie yubukorikori ifite kumenyekanisha molekile ya glucose. Imiterere iragoye cyane. Ni ukubera ko imiterere ya molekile ya glucose na isomers zayo (nka galactose, fructose, nibindi) birasa cyane, kandi bifite itsinda rimwe rukumbi rya hydroxyl ikora, bigoye kumenyekana neza muburyo bwa shimi. Imiti mike ya ligande yavuzwe ko ifite ubushobozi bwihariye bwo kumenya glucose hafi ya yose ifite ibibazo nkibikorwa bigoye bya synthesis.

Vuba aha, itsinda rya Porofeseri Yongmei Chen na Porofeseri wungirije Wang Renqi wo muri kaminuza y’ubumenyi n’ikoranabuhanga ya Shaanxi bafatanije na Associate Professor Mei Yingwu wo muri kaminuza ya Zhengzhou gutegura ubwoko bushya bushingiye kuri bidentate-hyd- Hydrogel ya cyclodextrin. Mugutangiza neza amatsinda asimburanya acide ya fenylboronike kuri 2,6-dimethyl-β-cyclodextrin (DMβCD), hashyizweho agace ka molekile gahuza imiterere ya topologiya ya D-glucose, ishobora guhuzwa cyane na molekile ya D- Glucose. no kurekura proton, bigatuma hydrogel yabyimba, bityo bigatuma insuline yabanjirijwe muri hydrogel irekurwa vuba mumaraso. Gutegura bidentate-β-cyclodextrin bisaba gusa intambwe eshatu zo kubyitwaramo, ntibisaba imiterere ikaze, kandi umusaruro wibisubizo ni mwinshi. Hydrogel yuzuye bidentate-β-cyclodextrin ihita isubiza hyperglycemia kandi ikarekura insuline mu mbeba ya diyabete yo mu bwoko bwa I, ishobora kugera ku kugenzura igihe kirekire urugero rwa glucose mu maraso mu masaha 12.