3D bioprinting tekinoroji yepamberi yekugadzira iyo inogona kuburitsa yakasarudzika maumbirwo uye zvimiro mune akaturikidzana-ne-layer nzira yemaseru akaiswa, zvichiita kuti iyi gadziriro iwedzere kuratidza yakasikwa multicellular chimiro chemidziyo yeropa. Mutsara wehydrogel bio-inks akaunzwa kugadzira zvimiro izvi; zvisinei, iyo inowanikwa bio-inks inogona kutevedzera kuumbwa kwechisikigo tsinga yeropa ine painogumira. Ikozvino bio-inks inoshaya kudhinda kwakanyanya uye haigone kuisa masero ehupenyu akanyanya-density muzvikamu zvakaoma zve 3D, nekudaro zvichideredza kugona kwavo.
Kuti vakunde zvikanganiso izvi, Gaharwar naJain vakagadzira itsva nano-engineered bio-ink kudhinda 3D, anatomically yakarurama tsinga dzeropa dzakawanda. Nzira yavo inopa yakagadziridzwa chaiyo-nguva kugadzirisa kwe macrostructures uye tishu-level microstructures, izvo parizvino hazvigoneke ne bio-inks.
Chinhu chakasiyana kwazvo cheiyi nano-engineered bio-ink ndechekuti zvisinei nekuwanda kwesero, inoratidza kudhindwa kwepamusoro uye kugona kuchengetedza maseru akavharirwa kubva kune yakakwira shear masimba panguva ye bioprinting process. Zvakakosha kuziva kuti 3D bio Masero akadhindwa anochengetedza phenotype ane hutano uye anoramba achishanda kweinenge mwedzi mushure mekugadzirwa.
Uchishandisa aya akasiyana hunhu, nano-engineered bio-inks anodhindwa mu 3D cylindrical tsinga dzeropa, iyo inoumbwa nehupenyu co-tsika dze endothelial masero uye vascular smooth tsandanyama masero, izvo zvinopa vaongorori mukana wekutevedzera mhedzisiro yemidziyo yeropa uye. zvirwere.
Ichi 3D bioprinted chigadziko chinopa chishandiso chinogoneka chekunzwisisa pathophysiology yezvirwere zvevascular uye kuongorora marapirwo, chepfu kana mamwe makemikari mune preclinical miedzo.
