Wnt inobatiswa nema receptors pane cell surface, izvo zvinokonzeresa kuwanda kwekuita mukati mesero. Yakawandisa kana mashoma masaini anogona kuve njodzi, izvo zvinoita kuti zviome kwazvo kudzidza nzira iyi uchishandisa nzira dzakajairwa dzinokurudzira sero repamusoro receptors.
Munguva yekukura kwe embryonic, Wnt inogadzirisa kukura kwenhengo dzakawanda, dzakadai semusoro, musana, uye maziso. Iyo zvakare inochengetedza stem maseru mumatishu akawanda muvakuru: Kunyangwe kusakwana kweWnt kusaina kunogona kukonzera kutadza kugadzirisa kwetishu, zvinogona kutungamira kune yakakwira Wnt kusaina mugomarara.
Zvakaoma kuwana chiyero chinodiwa kuburikidza nemaitiro akajairwa kudzora nzira idzi, senge makemikari kukurudzira. Kugadzirisa dambudziko iri, vatsvakurudzi vakagadzira puroteni yekugamuchira kuti ipindure kuchiedza chebhuruu. Nenzira iyi, vanogona kunyatso-tune Wnt nhanho nekugadzirisa kusimba uye nguva yechiedza.
"Chiedza senzira yekurapa yakashandiswa mu photodynamic therapy, iyo ine zvikomborero zvebiocompatibility uye hapana zvakasara zvakasara munzvimbo yakazaruka. Zvisinei, mishonga yakawanda yephotodynamic inowanzoshandisa chiedza kuti ibudise makemikari ane simba guru, akadai seanoita oxygen marudzi. Pasina. kusiyanisa pakati pezvinyama zvakajairwa uye matishu ane chirwere, kurapa kwakanangwa kunova kusingagoneke," Zhang akati: "Mubasa redu, takaratidza kuti mwenje webhuruu unogona kumisa nzira dzechiratidzo muzvikamu zvakasiyana zvematatya. Isu tinofungidzira zvakanaka. kuderedza dambudziko rehupfu husina chinangwa."
Vatsvakurudzi vakaratidza tekinoroji yavo uye vakasimbisa kuchinjika kwayo uye kunzwisiswa nekusimudzira kukura kwemusana uye musoro wematatya embryo. Ivo vakafungidzira kuti tekinoroji yavo inogona zvakare kushandiswa kune mamwe membrane-akasungwa receptors aratidza kunetsa kunanga, pamwe nedzimwe mhuka dzinogovana nzira yeWnt, kuti vanzwisise zviri nani kuti nzira idzi dzinodzora budiriro uye chii chinoitika kana dzapera.
"Apo isu tichiramba tichiwedzera hurongwa hwedu hwekuvhenekesa kuti huvhare dzimwe nzira dzekutanga dzekusimudzira embryonic, tichapa nharaunda inosimudzira biology seti yezvishandiso zvakakosha zvinogona kuvabatsira kuona mibairo yezviratidzo kumashure kwemaitiro mazhinji ebudiriro," Yang akadaro. .
Vatsvagiri vanotarisirawo kuti tekinoroji-yakavakirwa-mwenje yavanoshandisa kudzidza Wnt inogona kuvhenekera kugadzirisa kwetishu uye kutsvagisa kenza mumatishu evanhu.
"Nemhaka yekuti gomarara rinowanzo sanganisira masaini akanyanya-activated, isu tinofungidzira kuti chiedza-sensitive Wnt activators chinogona kushandiswa kudzidza kufambira mberi kwegomarara mumaseru mhenyu," akadaro Zhang. "Ichisanganiswa nehupenyu hwekufungidzira sero, tichakwanisa kuziva quantitatively kuti chii chinogona kushandura masero anowanzoita masero ane kenza. Chiratidzo chechiratidzo chinopa ruzivo rukuru rwekugadzirwa kwemishonga yakananga mumishonga yakarurama mune ramangwana."
