INONYANYA yakakamurwa kuva MEDICAL POLYPEPTIDE mishonga, peptide mishonga inorwisa mabhakitiriya, vaccine, zvekurima antimicrobial peptides, feed peptides, zuva nezuva chemikemikari cosmetics, SOYBEAN peptides chikafu, CORN peptides, mbiriso peptides, gungwa cucumber peptides.
Kubva pakuona kwekushanda, inogona kugoverwa kuva antihypertensive peptide, antioxidant peptide, cholesterol-kuderedza peptide, opioid inoshanda peptide, high F-value oligopeptide, chikafu chinonaka peptide nezvimwe zvakadaro.
Active peptide, ine hutano, hormone, enzyme inhibition, mutemo wekudzivirira, antibacterial, antiviral, antioxidant ine hukama hwepedyo. Peptides anowanzo kukamurwa kuita: peptide mishonga uye peptide hutano zvigadzirwa. Mishonga yechinyakare yepeptide inonyanya kuve mahomoni epeptide. Kugadzirwa kwemishonga yepeptide kwakagadzirwa munzvimbo dzakasiyana-siyana dzekudzivirira nekudzora zvirwere, kunyanya mundima dzinotevera.
Anti-tumor polypeptide
Tumorigenesis mhedzisiro yezvikonzero zvakawanda, asi pakupedzisira inosanganisira kudzorwa kweoncogene kutaura. Majena akawanda ane chokuita nebundu uye zvinhu zvekugadzirisa zvakawanikwa mu 2013. Kuongorora peptides iyo inosunga zvakananga kune aya majini uye zvinhu zvekugadzirisa zvave zvitsva zvitsva mukutsvaga mishonga inorwisa kenza. Semuenzaniso, somatostatin yakashandiswa kurapa endocrine tumors yegadziriro yekudya; Vatsvakurudzi veAmerica vakawana hexapeptide inogona kuvhara zvakanyanya adenocarcinoma mu vivo; Masayendisiti eSwitzerland akawana octapeptide inokonzera apoptosis mumasero emamota.
Antiviral polypeptide
Nekusunga kune chaiwo mareceptor pamasero anotambira, mavhairasi adsorb maseru uye anovimba neavo chaiwo maprotease ekugadzirisa mapuroteni uye nucleic acid kudzokorora. Naizvozvo, peptides inosungirira kugamuchira cell receptors kana nzvimbo dzinoshanda dzakadai sehutachiona proteases dzinogona kuongororwa kubva kuraibhurari yepeptide yekurapa antiviral. Muna 2013, Canada, Italy nedzimwe nyika dzakaongorora akawanda madiki peptides ane chirwere chekurwisa kubva kuraibhurari yepeptide, uye vamwe vacho vakapinda munhanho yekuedzwa kwekiriniki. Muna June 2004, Institute of Microbiology, Chinese Academy of Sciences yakashuma kuti nhungamiro yakakosha yeruzivo rwekuvandudza chirongwa chakaitwa neInstitute of Microbiology, Chinese Academy of Sciences, "Tsvakiridzo pamusoro pemaitiro eSARS-CoV cell fusion uye Fusion inhibitors", iyo yakaitwa pamwe chete neInstitute of Microbiology, Chinese Academy of Sciences neCentre for Modern Virology, Life Sciences, Wuhan University, yakanga yafambira mberi zvikuru. Miedzo yakaratidza kuti yakagadzirwa HR2 peptide inogona kunyatso kuvharidzira kutapukirwa kwemasero akagadzirwa nehutachiona hweSARS, uye iyo inoshanda inhibition concentration iri pakusangana kwema nmoles akati wandei. Kufambira mberi kwakakosha kwakaitwawo mukuedzwa kwehutachiona hwehutachiona hwehutachiona hwekugadzirwa uye kuratidzwa kweHR1 peptide uye in vitro inosunga kuyedza yeHR1 neHR2. Mishonga yepeptide yakagadzirwa kudzivirira kusanganiswa kwehutachiona hweSARS inogona kudzivirira kutapukirwa kwehutachiona uye, kana iri yevarwere vane hutachiona, kudzivirira kupararira kwehutachiona mumuviri. Mushonga wepolypeptide une zvese zvekudzivirira uye zvekurapa mabasa. Vatsvagiri paCell Engineering Research Center yeFourth Military Medical University vakagadzira mapeptide mapfumbamwe anogona kudzivirira nekumisa kupindira kwehutachiona hweSARS mumaseru.
Cytokines inotevedzera peptides
Kushandiswa kwema-receptors e-cytokines anozivikanwa kuti aone cytokine mimics kubva mumaraibhurari epeptide yave nzvimbo yekutsvakurudza muna 2011. Kuongororwa nevanhu kune dzimwe nyika erythropoietin, vanhu vanowedzera platelet hormone, kukura kwehomoni, kukura kwetsinga uye kuti zvakasiyana-siyana zvekukura zvinhu zvakadai se interleukin - 1 simulation peptide, simulation yepeptide amino acid sequence uye inowirirana cell factor yakasiyana, kutevedzana kwemaamino acids asi ine basa remacytokines, uye ine zvakanakira zvidiki.molecular uremu. Muna 2013 aya ma cytokine anotevedzera peptides ari pasi pe preclinical kana kiriniki yekuferefeta.
Antibacterial active peptide
Kana zvipembenene zvinokurudzirwa nemamiriro ekunze, nhamba huru ye cationic peptides ine antibacterial activity inogadzirwa. Muna 2013, marudzi anopfuura zana emaantimicrobial peptides akaongororwa. In vitro uye in vivo zviedzo zvakasimbisa kuti akawanda antimicrobial peptides haana chete yakasimba antibacterial uye bactericidal kugona, asiwo anogona kuuraya bundu maseru.
Peptide vaccine
Majekiseni ePeptide uye nucleic acid vaccines ndechimwe chezvinhu zvakakosha mundima yetsvagurudzo yejekiseni muna 2013. Tsvakurudzo yakawanda nekuvandudzwa kwemishonga yekudzivirira peptide yakaitwa munyika muna 2013. Semuyenzaniso, muna 1999, NIH yakaburitsa gwaro. mhedzisiro yekuongororwa kwekiriniki yemhando mbiri dzejekiseni reHIV-I virus peptide pane zvidzidzo zvevanhu; A polypeptide yakaongororwa kubva kunze membrane protein E2 yehepatitis C virus (HCV), iyo inogona kukurudzira muviri kuburitsa masoja ekudzivirira. United States iri kugadzira marariya polyvalent antigen polypeptide vaccine; Mushonga wepillomavirus peptide yemunhu wegomarara remuromo wechibereko wapinda muchikamu chechipiri chekiriniki miedzo. China yakaitawo basa rakawanda mukutsvaga kwemhando dzakasiyana dze polypeptide vaccine.
Peptides yekuongororwa
Kunyanya kushandiswa kwepeptides mune diagnostic reagents senge maantigen, masoja ekudzivirira ekuona anoenderana pathogenic organisms. Polypeptide maantigens akanyanya kujeka kupfuura ekuzvarwa hutachiona kana parasitic mapuroteni antigens uye ari nyore kugadzirira. Antibody kuona reagents akaunganidzwa ne polypeptide antigens muna 2013 anosanganisira: A, B, C, G chiropa chirwere utachiona, HIV, munhu cytomegalovirus, herpes simplex virus, rubella virus, Treponema pallidum, cysticercosis, trypanosoma, chirwere cheLyme uye rheumatoid kuona reagents. Mazhinji emaantigen epeptide akashandiswa akawanikwa kubva kupuroteni yekuzvarwa yemuviri unoenderana pathogenic, uye mamwe aive mapeptide matsva akawanikwa kubva kuraibhurari yepeptide.
