Human growth hormone (hGH) ihomoni yeendocrine inogadzirwa uye inochengetwa neanterior pituitary gland. hGH inogona kukurudzira kuumbwa kwe articular cartilage uye kukura kwe epiphyseal cartilage kuburikidza ne intergrowth hormone, iyo inokosha pakukura kwevanhu. Iyo zvakare inodzorwa nemamwe mahormone akavanzika ne hypothalamus. Kana kushomeka kwehGH kunogona kukonzera kusagadzikana kwekukura kwemuviri, zvichikonzera kupfupika. Kudzivirirwa kwehGH kunovharirwa mukati mekutenderera nenzira yekuputika, uye zvakaoma kuona HGH muropa kana iri mumugero wekuvhara. Inowedzerwa panguva yenzara, kurovedza muviri uye kurara. Iyo pituitary gland yemunhu achangoberekwa inotanga kuburitsa hGH pakupera kwemwedzi wechitatu, uye serum hGH level ye fetus inowedzera zvakanyanya, asi serum hGH yezinga revana vachangobva kuberekwa yakaderera, uye ipapo iyo secretion level inowedzera mukati. nhanho yehudiki, uye inosvika pakakwirira mukuyaruka, uye iyo secretion level yehGH inoderera zvishoma nezvishoma muvakuru vanopfuura makore makumi matatu. Vanhuwo zvavo vanoda hGH yekukura kwenguva refu, uye vana vane hGH kushomeka vapfupi muchimiro.
Muna 1958, Raben akatanga kutaura kuti kukura kwetishu kwevarwere vane hypophysial dwarf kwakavandudzwa zvakanyanya mushure mejekiseni remunhu pituitary extract. Zvisinei, panguva iyoyo, iyo chete inobva kune hGH yaiva yemunhu adenohypophysial gland ye autopsy, uye chiyero cheHGH chaigona kushandiswa kuchipatara chikumbiro chakanga chakanyanya kuderera. Angangoita 50 adenohypophysial glands aive akakwana kubvisa muyero weHGH waidiwa nemurwere mumwechete kwegore rimwe rekurapwa. Mamwe mahormone epituitary anogona zvakare kusvibiswa nekuda kwemaitiro ekuchenesa. Nekuvandudzwa kwesainzi uye tekinoroji, iko zvino zvave kugoneka kugadzira mahormone ekukura kwevanhu ne genetic engineering. hGH inogadzirwa nenzira iyi ine chimiro chakafanana nehGH mumuviri wemunhu nekuchena kwepamusoro uye zvishoma zvinokonzerwa nemigumisiro. Nekuda kwezviwanikwa zvakawanda zvezvinodhaka, kwete chete vana vane pituitary GHD vanogona kurapwa, asiwo kurapwa kwehupfupi hupfupi hunokonzerwa nezvimwe zvikonzero.
Uchishandisa kukura kwehomoni kurapa kupfupika, chinangwa ndechekubvumira mwana kubata, kuchengetedza mwero wenguva dzose wekukura, kuwana mukana wekukurumidza kuyaruka, uye pakupedzisira kusvika paurefu hwevakuru. Kureba kwenguva refu kwekiriniki kwakaratidza kuti kukura kwehomoni mushonga wakachengeteka uye unoshanda, uye kutanga kwekutanga kurapwa, zviri nani mhedzisiro yekurapa.
Kunyange zvazvo kukura kwehomoni inonziwo hormone, yakasiyana zvachose nehomoni yepabonde uye glucocorticoid maererano nekwakabva, chimiro chemakemikari, physiology, pharmacology nezvimwe zvinhu, uye haizobudisi migumisiro yehomoni yepabonde uye glucocorticoid. Kukura kwehomoni ihomoni yepeptide inovanzwa neanterior pituitary gland yemuviri wemunhu. Inoumbwa ne191 amino acids uye ine huremu hwema molecular 22KD. Kukura kwehomoni inotamba basa rayo rehupenyu nekukurudzira chiropa uye mamwe matukisi kuti abudise insulini-sekukura chinhu (IGF-1), kukurudzira kukura kwepfupa, kukurudzira muviri anabolism uye mapuroteni synthesis, kukurudzira lipolysis, nekudzivisa kushandiswa kweglucose. Pamberi pekuyaruka, kukura uye kukura kwemuviri wemunhu kunonyanya kuvimba nekukura kwehomoni uye thyroxine, kukura kwekuyaruka, kukura kwehomoni synergistic sex hormone, inosimudzira kukurumidza kukura kwehurefu, kana muviri wemwana usina kukura kwehomoni, zvinokonzera kukura kunonoka. , panguva ino, inoda kuwedzera exogenous kukura hormone.
