Mumuviri wemunhu, simba remetabolism rinonyanya kutsamira pane tricarboxylic acid cycle, iyo inoshandisa D-glucose sechinhu chesimba. Mukushanduka-shanduka kwenguva refu, muviri wemunhu wakagadzira yakaomesesa uye yakananga biological system inoziva uye metabolizes glucose mamorekuru. Nekuvandudzwa kwemararamiro evanhu, chirwere cheshuga, "muurayi akanyarara", akanganisa zvakanyanya hutano hwevanhu uye akaunza mutoro unorema wehupfumi kunzanga. Kuwanda kweglucose muropa uye jekiseni re insulin zvinounza kusagadzikana kuvarwere. Kune zvakare njodzi dzinogona kuitika dzakadai sekunetseka mukudzora jekiseni rejekiseni uye kupararira kwezvirwere zveropa. Naizvozvo, kuvandudzwa kwebionic biomaterials yekuburitswa kwehungwaru inodzorwa kuburitsa insulin ndiyo mhinduro yakanaka yekuwana kwenguva refu kutonga kwemazinga eglucose muropa muvarwere vane chirwere cheshuga.
Kune akawanda marudzi eglucose isomers mune zvese zvekudya uye mvura yemuviri yemuviri wemunhu. Iyo biological enzymes yemuviri wemunhu inogona kunyatso ziva mamorekuru eglucose uye ane dhigirii repamusoro. Nekudaro, kemisitiri yekugadzira ine chaiyo kucherechedzwa kwemamorekuru eglucose. Chimiro chacho chakaoma zvikuru. Izvi zvinodaro nekuti chimiro chemolecular yeglucose molecules uye isomers yayo (yakadai segalactose, fructose, etc.) yakafanana, uye ine imwechete hydroxyl inoshanda boka, izvo zvakaoma kunyatsozivikanwa nemakemikari. Iwo mashoma emakemikari ligands anonzi ane glucose-chaiyo yekuziva kugona anenge ese ane matambudziko akadai seyakaoma synthesis process.
Munguva ichangopfuura, chikwata chaProfessor Yongmei Chen uye Associate Purofesa Wang Renqi weShaanxi University of Science and Technology vakabatana naAssociate Purofesa Mei Yingwu weZhengzhou University kugadzira rudzi rutsva rwakavakirwa pabidentate-β- Hydrogel system ye cyclodextrin. Nekunyatso kuunza maviri ephenylboronic acid substituent mapoka pa2,6-dimethyl-β-cyclodextrin (DMβCD), molecular slit inoenderana neiyo topological chimiro cheD-glucose inoumbwa, iyo inogona kunyatsobatanidzwa neD-Glucose mamorekuru anosunga. uye kusunungura mapurotoni, zvichiita kuti hydrogel iwedzere, zvichiita kuti insulini yakarongedzerwa muhydrogel ikurumidze kubudiswa munzvimbo yeropa. Kugadzirira kwebidentate-β-cyclodextrin kunongoda matanho matatu ekugadzirisa, hakudi maitiro akaoma ekugadzirisa, uye chibereko chekuita chakakwirira. Iyo hydrogel yakatakurwa nebidentate-β-cyclodextrin inokurumidza kupindura hyperglycemia uye inobudisa insulini mumhando yeI diabetic mice, iyo inogona kuwana kutonga kwenguva refu kwemazinga eglucose yeropa mukati maawa gumi nemaviri.
