Tesamorelin peptide (INN) (zita rekutengeserana Egrifta) imhando yekugadzira yekukura-hormone-releasing hormone (GHRH) inoshandiswa mukurapa HIV-inobatanidza lipodystrophy, yakagamuchirwa pakutanga mu 2010. Inobudiswa uye yakagadzirwa neTheratechnologies, Inc. yeCanada. Mushonga uyu ipeptide yakagadzirwa ine ese makumi mana nemana amino acids emunhu GHRH pamwe nekuwedzera kweboka re trans-3-hexenoic acid.

Tesamorelin peptide inonzi stabilized synthetic peptide analogue ye hypothalamic peptide, Growth Hormone Releasing Hormone (GHRH) inoratidzirwa kuderedzwa kwemafuta akawandisa emudumbu muvarwere vane HIV vane lipodystrophy. Lipodystrophy chirwere chemetabolism chinoratidzwa nekuramba insulin, kugoverwa kwemafuta, uye hyperlipidemia inoenderana neantiretroviral therapy yehutachiona hweHIV.

Tesamorelin peptide ndeyekukura kwehomoni-inoburitsa hormone (GHRH) analog iyo yakaratidzwa kuwedzera kukura kwehomoni uye IGF-1 mazinga. Tesamorelin iye zvino ndiyo inonyanya kushanda GH kuburitsa hormone pamusika. Iyo injectable peptide inogadzira yakakura kugadzirwa kweHGH (Human Growth Hormone). Inosunga uye nekukurudzira vanhu GHRH receptors ine simba rakafanana seyedu yepanyama GHRH. Izvo hazvina kuratidzirwa zvakanyanya kukanganisa mamwe mahomoni epituitary mumuviri.

Gland Inokurudzirwa: Pituitary Gland

ZVINOBATSIRA TESAMORELIN:

Inowedzera zvakasikwa zvigadzirwa zveHGH (human growth hormone)

Inowedzera IGF-1 (Insulin Growth Factor - 1) pasina kuchinja glucose parameters

Yakaderedzwa triglycerides

Yakaderedzwa Visceral Adipose Tissue (VAT)

Yakaderedzwa Carotid Intima Media Size (cIMT)

Kuvandudzwa kwekuziva muvakuru pamusoro pemakore makumi matanhatu.

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