I-3D bioprinting yitekhnoloji yokuvelisa ephucukileyo enokuvelisa iimilo zeethishu ezizodwa kunye nezakhiwo ngendlela yomaleko-ngomaleko weeseli ezifakwe ngaphakathi, okwenza olu lungiselelo lubonakalise ngakumbi ubume bendalo be-multicellular bezakhiwo zemithambo yegazi. Uluhlu lwee-inks ze-hydrogel ze-bio-inks ziye zaziswa ukuyila ezi zakhiwo; nangona kunjalo, i-bio-inks ekhoyo enokulinganisa ukubunjwa kwemithambo yegazi yenyama yendalo inemida. I-bio-inks yangoku ayinakushicilelwa okuphezulu kwaye ayikwazi ukubeka iiseli eziphilayo ezinoxinano oluphezulu kwizakhiwo ezintsonkothileyo ze-3D, ngaloo ndlela zinciphisa ukusebenza kwazo.

Ukoyisa ezi ntsilelo, uGaharwar kunye noJain baphuhlise i-nano-engineered bio-inki ukuze baprinte i-3D, imithambo yegazi echanekileyo ye-anatomically. Indlela yabo ibonelela ngesisombululo esiphuculweyo sexesha langempela kwi-macrostructures kunye ne-microstructures yezinga lezicubu, okwangoku akunakwenzeka nge-bio-inks.

Into ekhethekileyo kakhulu yale nano-engineered bio-ink kukuba kungakhathaliseki ukuba i-cell density, ibonisa ukuprintwa okuphezulu kunye nokukwazi ukukhusela iiseli ezifakwe kwi-shear force ngexesha lenkqubo ye-bioprinting. Kuyafaneleka ukuba uqaphele ukuba i-3D bio Iiseli eziprintiweyo zigcina i-phenotype enempilo kwaye zihlala zisebenza phantse inyanga emva kokuveliswa.

Ukusebenzisa ezi mpawu zikhethekileyo, i-nano-engineered bio-inks iprintwa kwi-3D cylindrical blood vessels, equlethwe yinkcubeko ephilayo yeeseli ze-endothelial kunye neeseli ze-vascular smooth muscle, ezibonelela abaphandi ithuba lokulinganisa imiphumo yemithambo yegazi kunye nemithambo yegazi. izifo.

Esi sixhobo se-3D se-bioprinted sibonelela ngesixhobo esinokubakho sokuqonda i-pathophysiology yezifo ze-vascular kunye nokuvavanya unyango, i-toxins okanye ezinye iikhemikhali kwizilingo zangaphambili.