I-Anastrozole, i-estrogen buster

 KNOWLEDGE    |      2023-03-28

I-Estrogen busters


I-Anastrozole lichiza elinamandla le-antifemale le-aromatase inhibitor, elichiza elidumileyo lokulwa nabasetyhini phakathi kwabakhi bomzimba.


I-Anastrozole isetyenziswa ngabasebenzisi abaninzi be-steroid ngexesha lokujikeleza ukucinezela ukusabela kwe-inectation. Uninzi lwe-steroids aromatize kwaye lubangela i-estrogen side effects, apho i-anastrozole sisisombululo esihle. Ngokwenene kunciphisa amanqanaba e testosterone emzimbeni ngama-80 ekhulwini. Le yinzuzo ebalulekileyo kubasebenzisi be-steroid, kunye nokukhuthaza ukuveliswa kwehomoni ye-luteinizing kunye ne-follicle evuselela i-hormone.


Kubasebenzisi be-steroid, i-anastrozole inqanda imiphumo emibi ye-chiza ye-inofemale reaction. Ngenxa yokuba ezininzi i-steroids zivumba emzimbeni kwaye ziguqulwa zibe yi-estrogen, enokubangela iziphumo ezibi. Kwi-steroids, amanqanaba e-estrogen kubasebenzisi anyuka ukuya kumyinge ophindwe kasixhenxe phezulu kunabo bangabasebenzisi, nto leyo ebangela ugcino lwamanzi olumandla kunye nencam ye-bele ectosis ukuba iyekwa ingaqwalaselwanga. I-Aromatase inhibitors ezifana ne-anastrozole zezona zisebenzayo ekulawuleni i-oecytosis, ngelixa i-modulators ye-sex hormone ekhethiweyo efana ne-tamoxifen ingasebenzi kakhulu kune-dose ye-0.5-MG ixhaphake kakhulu kubasebenzisi be-steroid. Bambalwa kakhulu abantu abaya kufuna ngaphezu kwegigabyte enye, kwaye kwiimeko ezininzi yanele ngokugqibeleleyo. Kodwa iimbaleki zangaphambi kokhuphiswano zinokukufumanisa kuluncedo ukuthatha i-0.5MG ye-anastrozole ngosuku kangangeentsuku ezili-10 ukuya kwezili-14 ukuqinisa izihlunu.


Kukwacetyiswa ukuba ungeze i-anastrozole kwi-PCT yokubuyisela, enokugcina umlinganiselo we-estrogen kwi-testosterone ngaphakathi koluhlu oluqhelekileyo. Ukongeza, i-anastrozole yonyusa amanqanaba ehomoni ye-luteinizing kunye ne-follicle-stimulating hormone, kunye ne-testosterone ye-endo native inokubuyisela kwinqanaba eliqhelekileyo ngokukhawuleza.