I-Wnt ivulwa zii-receptors kumphezulu weseli, ezithi ziqalise uthotho lweentshukumo ngaphakathi kwiseli. Imiqondiso emininzi kakhulu okanye embalwa kakhulu inokuba yintlekele, nto leyo eyenza ukuba kube nzima kakhulu ukufunda le ndlela usebenzisa iindlela eziqhelekileyo ezivuselela i-cell surface receptors.
Ngexesha lokukhula kwe-embryonic, i-Wnt ilawula ukuphuhliswa kwamalungu amaninzi, njengentloko, intambo yomgogodla kunye namehlo. Ikwagcina iiseli ze-stem kwizicubu ezininzi kubantu abadala: Nangona ukungonelanga kwe-Wnt ukubonakaliswa kunokubangela ukungaphumeleli kokulungiswa kwezicubu, kunokukhokelela ekubonakalisweni kwe-Wnt ephakamileyo kumhlaza.
Kunzima ukufezekisa ibhalansi efunekayo ngeendlela eziqhelekileyo zokulawula ezi ndlela, ezifana nokuvuselela iikhemikhali. Ukusombulula le ngxaki, abaphandi baqulunqa iprotheni ye-receptor ukuphendula ukukhanya okwesibhakabhaka. Ngale ndlela, banokulungisa kakuhle inqanaba le-Wnt ngokulungelelanisa ubunzulu kunye nobude bokukhanya.
"Ukukhanya njengesicwangciso sonyango sisetyenzisiwe kwi-photodynamic therapy, enenzuzo ye-biocompatibility kwaye akukho mphumo eseleyo kwindawo eveleleyo. Nangona kunjalo, ezininzi zonyango lwe-photodynamic ngokuqhelekileyo zisebenzisa ukukhanya ukuvelisa iikhemikhali eziphezulu zamandla, ezifana neentlobo ze-oksijini ezisebenzayo. Ngaphandle kwe-oxygen esebenzayo. ukwahlula phakathi kwezicubu eziqhelekileyo kunye nezicubu ezigulayo, unyango olujoliswe kuyo luba lungenakwenzeka, "uZhang uthe: "Emsebenzini wethu, sibonise ukuba ukukhanya okuluhlaza okwesibhakabhaka kunokuvuselela iindlela zokubonisa kwiindawo ezahlukeneyo zeembryo zesele. ukunciphisa umceli mngeni wetyhefu ekujoliswe kuyo. "
Abaphandi babonise iteknoloji yabo kwaye baqinisekisa ukulungelelaniswa kwayo kunye novelwano ngokukhuthaza ukuphuhliswa kwentambo yomgogodla kunye nentloko ye-frog embryos. Bacinga ukuba itekhnoloji yabo ingasetyenziselwa kwezinye ii-receptors ezibotshwe kwi-membrane ezibonakalise ukuba kunzima ukujolisa, kunye nezinye izilwanyana ezabelana ngendlela ye-Wnt, ukuqonda ngcono ukuba ezi ndlela zilawula njani uphuhliso kunye nokuba kwenzekani xa ziphela.
"Njengoko siqhubeka nokwandisa inkqubo yethu yokukhanya ekukhanyeni ukugubungela ezinye iindlela ezisisiseko zokubonisa ukuphuhliswa kwe-embryonic, siya kubonelela uluntu lwebhayoloji yophuhliso kunye neseti yezixhobo ezixabisekileyo ezinokubanceda babone iziphumo zesignali emva kweenkqubo ezininzi zophuhliso," watsho uYang. .
Abaphandi banethemba lokuba itekhnoloji esekwe ekukhanyeni abayisebenzisayo ukufunda i-Wnt inokukhanyisa ukulungiswa kwezicubu kunye nophando lomhlaza kwizicubu zomntu.
“Ngenxa yokuba umhlaza uhlala ubandakanya imiqondiso esebenza ngokugqithisileyo, sinombono wokuba ii-activators ze-Wnt ezingakhathaliyo zingasetyenziselwa ukufunda ukuqhubeka komhlaza kwiiseli eziphilayo,” utshilo uZhang. "Ngokudityaniswa ne-imaging yeseli ephilayo, siya kukwazi ukugqiba ngokobungakanani ukuba yintoni enokuguqula iiseli eziqhelekileyo zibe ngamaseli omhlaza. Umda wesignali unika idatha ephambili yokuphuhliswa konyango oluthile olujoliswe kuyo kwiyeza elichanekileyo kwixesha elizayo."
