Ithiyori yokubonakalisa imfuza. Iihomoni zeSteroid zinobunzima obuncinci bemolekyuli kwaye zinyibilika kwilipid. Bangakwazi ukungena kwiiseli ekujoliswe kuzo ngokusasazwa okanye ukuthuthwa komthwali. Emva kokungena kwiiseli, i-hormone ye-steroid ibophelela kwi-receptors kwi-cytosol ukwenza i-hormone-receptor complexes, enokuthi iqhube i-allosteric translocation ngokusebenzisa i-membrane yenyukliya phantsi kobushushu obufanelekileyo kunye ne-Ca2 + inxaxheba.
Emva kokungena kwi-nucleus, i-hormone ibophelela kwi-receptor kwi-nucleus ukwenza i-complex. Le ngqungquthela ibophelela kwiindawo ezithile kwi-chromatin engeyiyo i-histones, iqala okanye inqanda inkqubo yokubhala i-DNA kule ndawo, kwaye emva koko ikhuthaza okanye inqanda ukubunjwa kwe-mRNA. Ngenxa yoko, ibangela okanye inciphisa ukuhlanganiswa kweeprotheni ezithile (ikakhulukazi i-enzymes) ukufezekisa iziphumo zayo zezinto eziphilayo. Imolekyuli yehomoni enye inokuvelisa amawaka eemolekyuli zeprotheyini, ngaloo ndlela ifezekisa umsebenzi owandisiweyo wehomoni.
Ukuphendula kweHormone Ngexesha lomsebenzi we-muscle, amanqanaba amahomoni ahlukeneyo, ngakumbi lawo ahlanganisa ukunikezelwa kwamandla, atshintshe kwiidigri ezihlukeneyo kwaye achaphazele inqanaba le-metabolism yomzimba kunye nenqanaba lokusebenza kwezitho ezahlukahlukeneyo. Ukulinganisa amanqanaba eehomoni ezithile ngexesha nasemva kokuzilolonga kunye nokuwathelekisa namaxabiso azolileyo kubizwa ngokuba yi-hormonal response to exercise.
I-HORMONES eziphendula ngokukhawuleza, ezifana ne-EPINEPHRINE, i-NOrepINEPHRINE, i-CORTISOL, kunye ne-ADRENOCORTICOTROPIN, ZIPHATHELE NGOKUBALULEKILEYO kwi-plasma NGOKUNGOKO EMVA KOMSEBENZI kwaye iphakame ngexesha elifutshane.
Amahomoni asebenzayo aphakathi, afana ne-aldosterone, i-thyroxine, kunye ne-pressor, akhuphuka ngokukhawuleza kwaye ngokuthe ngcembe kwi-plasma emva kokuqala komthambo, afikelele kwincopho phakathi kwemizuzu.
Iihomoni zokuphendula ezicothayo, ezifana ne-hormone yokukhula, iglucagon, i-calcitonin kunye ne-insulin, azitshintshi ngokukhawuleza emva kokuqala komthambo, kodwa zinyuka ngokukhawuleza emva kwe-30 ukuya kwi-40min yokuzivocavoca kwaye ifike kwincopho kamva.
