I-Auxin ingasetyenziselwa ukunyanga ukukhula kophuhliso olubangelwa kukusilela kwehomoni yokukhula.

Ihomoni yokukhula, ekwabizwa ngokuba yihomoni yokukhula komntu (hgh), yihomoni yepeptide evaliweyo ukuba isetyenziswe kwezemidlalo kwaye iqhele ukusetyenziselwa ukunyanga ubuncinci. Ineempembelelo zokwenziwa kunye ne-metabolism eyandisa ubunzima be-muscle, ikhuthaza ukukhula kwamathambo kubantwana nakwishumi elivisayo, kunye nokuqinisa imisipha kunye nezitho zangaphakathi. Iimbaleki zisebenzisa iGH ngokungekho mthethweni ngokuyintloko ukwakha izihlunu kunye namandla okufumana inzuzo yokukhuphisana.

Ngokoncwadi, i-injection engaphantsi kwe-subcutaneous okanye ye-intramuscular isebenza ngokulinganayo, kwaye i-injection ye-subcutaneous idla ngokuzisa i-serum GH concentrations ephezulu kune-injection ye-intramuscular, kodwa i-IGF-1 i-concentration iyafana. Ukufunxa kwe-GH kudla ngokucotha, kunye noxinzelelo lwe-plasma lwe-GH ludla ngokuphakama kwi-3-5 h emva kokulawulwa, kunye nesiqingatha sobomi be-2-3 h. I-GH ihlanjululwa ngesibindi kunye nezintso, ngokukhawuleza kubantu abadala kunabantwana, kwaye ukupheliswa ngokuthe ngqo kwe-GH engaxutywanga kumchamo kuncinci. Iimpawu: Ukunyanga ukukhula okucothayo kunye nokutshisa okukhulu kubantwana abanokusilela kwehomoni engapheliyo, ukungaphumeleli kwezintso, kunye ne-Turner syndrome.

Kutheni ukuveliswa kwehomoni yokukhula komntu kuncipha ngobudala:

I-self-feedback loops kwisenzo. Xa i-IGF-l iyancipha emzimbeni, imiqondiso ithunyelwa kwi-pituitary gland ukuze ikhuphe i-hGH eninzi, kwaye lo msebenzi we-autogenous feedback loop uyancipha ngokukhula.