Izazinzulu zaseMelika zafunda indlela yebhayoloji emva kokutshiswa kwamafutha, zichonge iprotheni edlala indima ephambili ekulawuleni imetabolism, kwaye yangqina ukuba ukuthintela umsebenzi wayo kunokukhuthaza le nkqubo kwiimpuku. Le proteni ebizwa ngokuba yi-Them1 iveliswa kumanqatha amdaka omntu, inika umkhombandlela omtsha kubaphandi ukuba bafune unyango olusebenzayo ngakumbi lokutyeba.
Izazinzulu ezisemva kolu phononongo olutsha ziye zafunda i-Them1 malunga neminyaka elishumi, kwaye banomdla kwindlela iigundane ezivelisa ngayo iiprotheyini ezinkulu kwiithishu zazo ezimdaka ze-adipose phantsi kobushushu obubandayo. Ngokungafaniyo nezicubu ze-adipose ezimhlophe ezigcina amandla amaninzi emzimbeni njenge-lipids, izicubu ze-adipose ezimdaka zitshiswa ngokukhawuleza ngumzimba ukuvelisa ubushushu xa sibanda. Ngenxa yesi sizathu, izifundo ezininzi ezichasene nokutyeba zijolise kwiinzame zokuguqula amanqatha amhlophe abe ngamafutha amdaka.
Abaphandi banethemba lokuphuhlisa imifuniselo esekwe kolu phononongo lwakwangoko lwempuku apho iimpuku ziguqulwa ngokwemfuza ukuze zingabi nazo1. Kuba babecingela ukuba i-Them1 yayinceda iimpuku ukuba zivelise ubushushu, babelindele ukuba ukuyikhupha kuya kunciphisa isakhono sabo sokwenza oko. Kodwa kuyavela ukuba ngokuchaseneyo, iimpuku eziswele le proteni zidla amandla amaninzi okuvelisa iikhalori, ukuze zibe ziphindwe kabini njengeempuku eziqhelekileyo, kodwa ziyancipha ubunzima.
Nangona kunjalo, xa ucima uhlobo lwe-Them1, imouse iya kuvelisa ubushushu obuninzi, hayi ngaphantsi.
Kuphando olusanda kupapashwa, izazinzulu ziye zahlola izizathu ezibangela le nto ingalindelekanga. Oku kubandakanya ukujonga ifuthe le-Them1 kwiiseli zamafutha amdaka akhule elabhoratri kusetyenziswa imikroskopu yokukhanya kunye ne-electron. Oku kubonisa ukuba njengoko amanqatha eqala ukutshisa, iimolekyuli zeThem1 ziba notshintsho lweekhemikhali, ezibangela ukuba zisasazeke kwiseli.
Enye yeempembelelo zoku kusasazeka kukuba i-mitochondria, eyaziwa ngokuba yi-cell dynamics, iyakwazi ukuguqula ukugcinwa kwamafutha kumandla. Nje ukuba i-fat burning stimulation iyeke, iprotein ye-Them1 iya kuphinda ilungelelanise ngokukhawuleza ibe kwisakhiwo esiphakathi kwe-mitochondria kunye namafutha, kwakhona inciphisa ukuveliswa kwamandla.
I-high-resolution imaging ibonisa: Iprotheyini ye-Them1 isebenza kwi-brown adipose tissue, ihlelwe kwisakhiwo esithintela ukuvutha kwamandla.
Olu phononongo luchaza indlela entsha elawula imetabolism. I-Them1 ihlasela umbhobho wamandla kwaye inqumle unikezelo lwamafutha kwi-mitochondria etshisa amandla. Abantu bakwanawo namafutha amdaka, aza kuvelisa ngaphezulu kwe-Them1 phantsi kweemeko ezibandayo, ke ezi zinto zifunyanisiweyo zinokuba neziphumo ezinomdla kunyango lokutyeba.
