KAKHULU yahlulwe ngamachiza e-MEDICAL POLYPEPTIDE, i-peptide antibiotics, amayeza okugonya, i-peptides ye-antimicrobial yezolimo, i-peptides yokutya, izithambiso zemichiza yemihla ngemihla, iipeptides zeSOYBEAN zokutya, i-CORN peptides, i-yeast peptides, i-peptides ye-cucumber yolwandle.

Ukusuka kwimbono yokusebenza, inokwahlulwa ibe yi-peptide ye-antihypertensive, i-peptide ye-antioxidant, i-peptide yokunciphisa i-cholesterol, i-peptide esebenzayo ye-opioid, i-oligopeptide ephezulu ye-F, i-peptide yokutya kunye nokunye.

I-peptide esebenzayo, enesondlo, ihomoni, inhibition ye-enzyme, ukulawulwa kwe-immune, i-antibacterial, i-antiviral, i-antioxidant inobudlelwane obusondeleyo kakhulu. Iipeptides zohlulwe ngokubanzi zibe: amayeza epeptide kunye neemveliso zempilo zepeptide. Amachiza esintu eepeptide ikakhulu ziihomoni zepeptide. Ukuphuhliswa kwamachiza epeptide kuye kwaphuhliswa kwiinkalo ezahlukeneyo zothintelo nolawulo lwezifo, ngakumbi kula macandelo alandelayo.

I-polypeptide ye-anti-tumor

I-Tumorigenesis yisiphumo sezinto ezininzi, kodwa ekugqibeleni ibandakanya ukulawulwa kwe-oncogene expression. Uninzi lwezakhi zofuzo ezinxulumene ne-tumor kunye nezinto ezilawulayo zifunyenwe kwi-2013. Iipeptides zokuhlola ezibophelela ngokuthe ngqo kwezi zakhi zofuzo kunye nezinto ezilawulayo ziye zaba yindawo entsha ekufuneni izidakamizwa ze-anticancer. Ngokomzekelo, i-somatostatin isetyenziswe ukunyanga izicubu ze-endocrine zenkqubo yokutya; Abaphandi baseMerika bafumene i-hexapeptide enokuthintela kakhulu i-adenocarcinoma kwi-vivo; Izazinzulu zaseSwitzerland ziye zafumanisa i-octapeptide eyenza i-apoptosis kwiiseli zethumba.

I-Antiviral polypeptide

Ngokuzibophelela kwii-receptors ezithile kwiiseli zomkhosi, iintsholongwane zibhengeza iiseli kwaye zithembele kwiiproteases zazo ezithile zokusetyenzwa kweeprotheyini kunye nokuphindaphinda kwe-nucleic acid. Ke ngoko, iipeptides ezibophelela kwii-receptors zeeseli okanye iisayithi ezisebenzayo ezifana ne-viral proteases zinokujongwa kwithala leencwadi le-peptide kunyango lwe-antiviral. Ngo-2013, iCanada, i-Italiya namanye amazwe avavanye iipeptide ezininzi ezincinci ezinokuxhathisa izifo kwithala leencwadi le-peptide, kwaye ezinye zazo ziye zangena kwinqanaba lolingo lwezonyango. NgoJuni 2004, iZiko leMicrobiology, iAcademy yaseTshayina yeSayensi yabika ukuba isikhokelo esibalulekileyo solwazi lweprojekthi eyenziwe yiZiko leMicrobiology, iChinese Academy yeSayensi, "uPhando kwindlela ye-SARS-CoV yokudityaniswa kweeseli kunye ne-Fusion inhibitors", eyayiqhutywa ngokudibeneyo liZiko leMicrobiology, iAkhademi yaseTshayina yeSayensi kunye neZiko leVirology yanamhlanje, iSayensi zoBomi, iYunivesithi yaseWuhan, yenze inkqubela phambili ebonakalayo. Iimvavanyo zibonakalise ukuba i-peptide eyiliweyo ye-HR2 inokuthintela ngokufanelekileyo usulelo lweeseli ezikhuliswe yintsholongwane ye-SARS, kwaye ugxininiso olusebenzayo lothintelo kukuxinaniso lwee-nmoles ezininzi. Inkqubela phambili ebalulekileyo iye yenziwa kwimifuniselo yothintelo losulelo lwentsholongwane edityanisiweyo kunye nechaziweyo ye-HR1 peptide kunye nemifuniselo ebophelelayo ye-in vitro ye-HR1 kunye ne-HR2. Amachiza e-peptide aphuhliswe ukuthintela ukudityaniswa kwentsholongwane ye-SARS anokuthintela usulelo lwentsholongwane kwaye, kwimeko yezigulana ezosulelekileyo, athintele ukusasazeka kwentsholongwane emzimbeni. Ichiza le-polypeptide linemisebenzi yokuthintela kunye neyonyango. Abaphandi kwiZiko loPhando lobuNjineli beSeli kwiYunivesithi yesine yoNyango lwezoNyango baye bahlanganisa iipeptide ezilithoba ezinokuthintela ngokufanelekileyo kwaye zithintele uhlaselo lwentsholongwane ye-SARS kwiiseli.

Iicytokines zilinganisa iipeptides

Ukusetyenziswa kwe-receptors kwii-cytokines ezaziwayo ukukhangela i-cytokine elinganisayo kwiilayibrari ze-peptide iye yaba yindawo yophando ngo-2011. Ukuhlolwa ngabantu bangaphandle kwe-erythropoietin, abantu bonyusa ihomoni yeplatelet, ihomoni yokukhula, ukukhula kwemithambo-luvo kunye nokuba izinto ezahlukeneyo zokukhula ezifana ne-interleukin - I-peptide yokulinganisa i-1, ukulinganisa kwe-peptide amino acid ulandelelwano kunye ne-cell factor ehambelana nayo yahlukile, ukulandelelana kwee-amino acids kodwa inomsebenzi we-cytokines, kwaye ineenzuzo ezincinci.ubunzima bemolekyuli. Ngo-2013 ezi peptides zilingisa iicytokine ziphantsi kophando lwangaphambili okanye lwezonyango.

I-antibacterial peptide esebenzayo

Xa iinambuzane zikhuthazwa yimeko yangaphandle, inani elikhulu leepeptide ze-cationic kunye nomsebenzi we-antibacterial ziveliswa. Ngo-2013, ngaphezu kwe-100 iintlobo ze-antimicrobial peptides ziye zahlolwa. Iimvavanyo ze-in vitro kunye ne-vivo ziqinisekisile ukuba iipeptide ezininzi ze-antimicrobial azinayo nje amandla e-antibacterial kunye ne-bactericidal, kodwa zinokubulala iiseli zethumba.

Ugonyo lwePeptide

Izitofu zokugonya ze-Peptide kunye ne-nucleic acid yokugonya yayiyenye yezona zinto zibaluleke kakhulu kwinkalo yophando lwesitofu ngo-2013. Uphando oluninzi kunye nophuhliso lwezitofu ze-peptide zentsholongwane zenziwa kwihlabathi kwi-2013. Ngokomzekelo, kwi-1999, i-NIH yapapasha iziphumo zolingo lwezonyango lweentlobo ezimbini zezitofu zentsholongwane ye-HIV-I kwi-peptide kubantu; I-polypeptide yahlolwa kwiprotheni ye-membrane yangaphandle ye-E2 ye-virus ye-hepatitis C (HCV), enokuvuselela umzimba ukuba uvelise izilwa-buhlungu ezikhuselayo. I-United States iphuhlisa isitofu sokugonya se-malaria polyvalent antigen polypeptide; Isitofu sokugonya se-human papillomavirus peptide yomhlaza womlomo wesibeleko singene kwisigaba sesi-II solingo lwezonyango. I-China yenze umsebenzi omninzi kuphando lweentlobo ezahlukeneyo zezitofu zokugonya i-polypeptide.

Iipeptides zokuxilongwa

Ukusetyenziswa okuphambili kweepeptide kwii-reagents zokuxilonga kufana ne-antigens, i-antibodies ukufumanisa i-pathogenic organisms ehambelanayo. Ii-antigens ze-Polypeptide zithe ngqo ngakumbi kune-antigens ye-microbial okanye i-parasitic protein kwaye kulula ukuyilungisa. I-antibody reagents ehlanganiswe ne-polypeptide antigens ngo-2013 iquka: i-A, B, C, i-virus yesifo sesibindi se-G, i-HIV, i-cytomegalovirus yabantu, i-herpes simplex virus, i-rubella virus, i-Treponema pallidum, i-cysticercosis, i-trypanosoma, isifo se-Lyme kunye ne-reagents yokufumanisa i-rheumatoid. Uninzi lwee-antigens ze-peptide ezisetyenzisiweyo zafunyanwa kwiprotheni yendalo yomzimba ohambelana ne-pathogenic, kwaye ezinye yayizipeptide ezintsha ngokupheleleyo ezifunyenwe kwithala leencwadi.