Intshayelelo yeMGF:
I-Mechano Growth Factor Mechano Growth Factor, eyaziwa nje ngokuba yi-MGF, i-splice variant ye-IGF-1, i-splice factor/repair factor derived from exercise or damaged muscle tissues, Yenza kube nzima ukuchonga ezinye iintlobo ze-IGF.
Yintoni eyenza i-MGF ekhethekileyo yindima yayo ekhethekileyo ekukhuleni kwemisipha. I-MGF inekhono elikhethekileyo lokukhuthaza ukukhula kwezicubu ezimoshayo kunye nokuphucula ngokuvula iiseli ze-muscle stem kunye nokwandisa ukulawulwa kweprotheni synthesis. Olu buchule bukhethekileyo buphucula ngokukhawuleza ukubuyiswa kunye nokukhawuleza ukukhula kwemisipha. Ukongeza kwi-IGF-1 ye-receptor domain, i-MGF iphinda iqalise i-muscle satellite (i-stem cell) i-cell activation, ngaloo ndlela inyusa i-protein synthesis turnover; Ngoko ke, ukuba isetyenziswe ngokufanelekileyo, inokuphucula kakhulu ubunzima bemisipha.
I-IGF-1 i-hormone ye-70-amino acid enesakhiwo esifana ne-insulin efihliweyo yisibindi, kwaye i-IGF-1 i-secretion ithonywa yi-secretion kunye nokukhululwa kwe-hormone yokukhula (GH) emzimbeni. I-IGF-1 ichaphazela phantse yonke iseli emzimbeni, ikakhulu ngenxa yokuba ibandakanyeka ekulungisweni kweeseli. Xa izicubu zomzimba zonakalisiwe, oku kudala ukusabela emzimbeni obizwa ngokuba yi-T
I-IGF-1 idityaniswe kwiintlobo ezimbini, i-IGF-1Ec kunye ne-IGF-1Ea, eyayisakuba yiMGF.
Ukwahluka kwe-MGF yee-IGF ezimbini eziveliswe sisibindi:
Eyokuqala yi-IGF-1EC: eli linqanaba lokuqala lokukhulula ukwahluka kwe-igf, kwaye
Ivuselela ukusebenza kweeseli zesathelayithi
Okwesibini i-IGF-IEA ye-hepatic: Oku kukukhululwa kwesibini kwe-igf kwisibindi, kunye neenzuzo zayo ze-anabolic zincinci kakhulu kunezokuqala.
I-MGF ihluke kwi-second variant, IGF-IEa, ngokuba ine-peptide yokulandelelana eyahlukileyo kwaye inoxanduva lokuzalisa iiseli zesathelayithi kwi-skeletal muscle; Ngamanye amazwi, inikezela ngeenzuzo ezininzi ze-anabolic kunye nemiphumo emide kunenkqubo ye-MGF yesibini yesibindi.
Ke kufuneka ucinge nje nge-MGF njengokwahluka okuphuculwe kakhulu kwe-igf ngokweenzuzo ze-anabolic. Emva koqeqesho, i-IGF-I gene splices MGF kwaye emva koko ibangela i-hypertrophy kunye nokulungiswa komonakalo wemisipha yendawo ngokuvula iiseli ezomileyo ze-muscle kunye nezinye iinkqubo ezibalulekileyo ze-anabolic (kubandakanywa neprotheni synthesis echazwe ngasentla) kunye nokwandisa ukugcinwa kwe-nitrogen kwi-muscle.
Kwiigundane, ezinye izifundo zibonise ukwanda kwe-20% kwi-muscle mass nge-injection eyodwa ye-MGF, kodwa ndicinga ukuba ezininzi zezi zifundo azichanekanga, kodwa amandla e-MGF angenakuphikiswa.
I-splicing ye-MGF ivuselela iiseli zesathelayithi, ezikhokelela ekukhuleni kwemicu emitsha yemisipha emzimbeni. Ukongeza, ubukho beMGF kwandisa izinga leprotheyini yomzimba, ngaloo ndlela kukhuthaza i-myohypertrophy kunye nokwandisa! Yiba nkulu! Yiba nkulu! Ewe kubaluleke ngakumbi ukulungisa i-196 ekhoyo
Ngokuqinisekileyo, izinto zokubuyisela ezinxulumene ne-MGF ngokungathandabuzekiyo yeyona ndawo inomtsalane kwi-MGF.
Ngelixa ukusebenza kwe-MGF kunokubonakala kubhideka kancinci xa uthi nqala, inkqubo ngokwayo iba lula xa uyijonga inyathelo ngenyathelo:
I-1.IGF-1 ikhutshwe ngokuzilolonga (kwenzeka emva kokuzivocavoca)
2. I-Splice IGF-1 kunye ne-MGF
I-3.MGF ivuselela ukubuyiswa kwezicubu ze-muscle emva kokulimala koqeqesho ngokuvula iiseli ze-muscle stem
Ukusetyenziswa kweMGF
Kwenzeka ntoni kwizihlunu zakho xa uziqeqesha? Ziyaqhekeka, iiseli zonakaliswe, izicubu zemisipha zifuna ukulungiswa, kwaye umzimba wakho uvelisa iintlobo ezimbini zeMGF zokwahluka kwe-splicing. Ukukhutshwa kokuqala kokuqala kwesibindi se-1 ukuhluka apha ngasentla kuququzelela ukubuyiswa kweeseli ze-muscle. Kuthekani ukuba iMGF yayingekho? Ngokulula, iiseli zezihlunu azilungisi kwaye ziyafa. Iiseli zezihlunu ziiseli ezivuthiweyo ezingakwaziyo ukwahlulahlula, iiseli zezihlunu ziphuma kwiiseli ezizihlunu ezahlulahlulwe kwiiseli zezihlunu ngokusebenzisa i
mitosis, ngoko ke umzimba awukwazi ukulungisa izicubu ngokutshintshwa kweeseli emva komonakalo wemisipha, unokulungisa kuphela iiseli zokuqala, ukuba iiseli azilungiswanga, ziya kufa. Izihlunu zakho ziya kuba ncincikwaye buthathaka. Ngokusebenzisa i-MGF, ukubuyiswa komzimba kunokukhawuleziswa kwaye iiseli zezicubu zemisipha zinokunyuswa ngokuvuselela ukuvuthwa ngokupheleleyo kweeseli zesathelayithi. Ngokumalunga nedosi, 200mcg naliti indawo ezimbini lolona khetho lungcono (inaliti indawo iyafuneka MGF). Ingxaki kuphela MGF kukuba isiqingatha-ubomi bayo mfutshane kakhulu, kuphela 5-7 imizuzu, kwaye kufuneka isetyenziswe ngoko nangoko emva koqeqesho ukufumana iziphumo ezingcono, ngelixa abantu abaninzi abanalo ixesha lokuyisebenzisa ngexesha le festile. emva koqeqesho.
Yintoni i-PEG-MGF?
Njengoko kukhankanyiwe ngasentla, eyona nto inkulu ye-MGF yithuba layo elifutshane lomsebenzi, ngoko ke inguqulelo yexesha elide ye-MGF, PEG MGF, yenziwe. Ngokungongeza i-PEG (i-polyethylene glycol, i-additive non-toxic) kwi-MGF, i-half-life ye-MGF inokunyuswa ukusuka kwimizuzu ukuya kwiiyure. Ixesha elongeziweyo lomsebenzi lithetha ukuba ukusetyenziswa kwayo kunye nokuguquguquka kuya kuphuculwa kakhulu, kwaye i-PEG MGF inefuthe lenkqubo apho i-muscle yonakaliswe okanye inesifo, kunokuba inqunyelwe kwindawo enye.
Ndiyisebenzisa njani PEG-MGF
Indawo elandelayo ekufuneka sigxininise kuyo yindlela yokufumana okuninzi kuguqulelo oluthatha ixesha elide lweMGF. Xa izihlunu zakho zonakaliswe, umzimba wakho ukhulula i-pulses ye-MGF i-clip-on variant echazwe ngasentla, ilandelwa yifomu elide elide elivela kwisibindi kunye neenzuzo eziphantsi ze-anabolic. Ngoko kubonakala ngathi inkunkuma yokutofa i-MGF ngeli xesha, kuba wenza buthathaka kuphela ukukhululwa komzimba, kungekhona ukuyiphucula. Ke ngoko, ukusebenzisa i-PEG MGF ngeentsuku zokungazilolongi yeyona ndlela ilungileyo. Ngenxa yomonakalo wemisipha, i-MGF inama-receptors amaninzi, kwaye iziphumo zayo ziyinkqubo. Ngokunyusa ukugcinwa kwe-nitrogen, ukuguqulwa kweprotheyini kunye nokusebenza kweeseli zesathelayithi, kuya kunceda ukubuyisela zonke izihlunu. Ngokwenza njalo, uyakwandisa ubude bexesha elithatha umzimba wokulungisa izihlunu kunye neendlela zokukhula. Ukusebenzisa i-PEG MGF ngokubambisana ne-IGF igqibelele, kodwa ngenxa ye-receptor affinity eqinile ye-IGF, ukuba usebenzisa zombini i-IGF-1 kunye ne-PEG MGF, ukusebenza kwe-MGF kuya kuncitshiswa.
Iingcebiso zam zezi zilandelayo:
I-IGF DES okanye i-IGF1-LR3 isetyenziswa kwiintsuku zoqeqesho ngaphambi koqeqesho, olungaphazamisi ukukhululwa kwe-MGF kwisibindi somzimba. I-IGF-DES yayisetyenziselwa ukuphucula ngokukhawuleza indawo egciniweyo, kwaye emva koko i-MGF ye-200-400 MCG isetyenziswe ngosuku olulandelayo ukunyusa indlela yokubuyisela kunye nokukhula. I-synergy egqibeleleyo.
PEG MGF yokugcina
I-MGF inokugcinwa efrijini ukuya kwiinyanga ezintandathu. Kuphephe ukuchanabeka kubushushu okanye elangeni
