Ihomoni yokukhula komntu (hGH) yihomoni ye-endocrine eveliswa yaza yagcinwa lidlala elingaphambili lepituitary. I-hGH inokukhuthaza ukubunjwa kwe-articular cartilage kunye nokukhula kwe-epiphyseal cartilage ngokusebenzisa i-hormone ye-intergrowth, eyimfuneko ekukhuleni komntu. Ikwalawulwa ngamanye amahomoni afihliweyo yi-hypothalamus. Ukuba ukunqongophala kwe-hGH kunokubangela ukuphazamiseka kokukhula komzimba, kubangele ubude obufutshane. Imfihlo ye-hGH ifihliwe kwi-circulation ngendlela ye-pulse, kwaye kunzima ukufumanisa i-HGH egazini xa isendaweni yokufihla. Yandiswa ngexesha lendlala, ukuzivocavoca kunye nokulala. Idlala lepituitary lomntwana ongekazalwa liqala ukukhupha i-hGH ekupheleni kwenyanga yesithathu, kwaye inqanaba leserum ye-hGH ye-fetus liye landa kakhulu, kodwa inqanaba leserum ye-hGH yeentsana ezizelwe ixesha elipheleleyo liphantsi, kwaye ke inqanaba lokukhuselwa liyenyuka. inqanaba lobuntwana, kwaye lifikelela kwincopho yokufikisa, kwaye inqanaba lokukhuselwa kwe-hGH liyehla ngokuthe ngcembe kubantu abadala abangaphezu kweminyaka engama-30 ubudala. Abantu abaqhelekileyo badinga i-hGH yokukhula kwe-longitudinal, kwaye abantwana abane-hGH yokunqongophala bafutshane ngesiqu.
Ngo-1958, uRaben waqala waxela ukuba ukukhula kwezicubu zezigulana ezine-hypophysial dwarf kwaphuculwa kakhulu emva kokutofwa kwencindi yepituitary yomntu. Nangona kunjalo, ngelo xesha, umthombo kuphela we-hGH yayiyi-adenohypophysial gland yomntu kwi-autopsy, kwaye inani le-hGH elinokusetyenziswa kwisicelo seklinikhi lalilinganiselwe kakhulu. Kuphela malunga namadlala angama-50 e-adenohypophysial ayenele ukukhupha umthamo we-HGH ofunekayo sisigulana esinye unyaka omnye wonyango. Ezinye iihomoni zepituitary nazo zinokungcoliseka ngenxa yeendlela zokucoca. Ngophuhliso lwesayensi kunye nobuchwepheshe, ngoku kunokwenzeka ukuvelisa i-hormone yokukhula komntu ngobunjineli bezofuzo. I-hGH eveliswa yile ndlela inesakhiwo esifanayo ne-hGH emzimbeni womntu ngokucoceka okuphezulu kunye nemiphumo embalwa. Ngenxa yemithombo eninzi yeziyobisi, kungekhona nje abantwana abane-GHD ye-pituitary abanokuphathwa, kodwa kunye nokunyangwa kwesigxina esifutshane esibangelwa ezinye izizathu.
Ukusebenzisa i-hormone yokukhula ukunyanga ubude obufutshane, injongo kukuvumela umntwana ukuba abambe, alondoloze izinga eliqhelekileyo lokukhula, athole ithuba lokufikisa ngokukhawuleza, kwaye ekugqibeleni afikelele kubude bomntu omdala. Uqheliselo lweklinikhi lwexesha elide lubonakalise ukuba ihomoni yokukhula lichiza elikhuselekileyo nelisebenzayo lonyango, kwaye kwangethuba ukuqala konyango, ngcono isiphumo sonyango.
Nangona i-hormone yokukhula ikwabizwa ngokuba yi-hormone, ihluke ngokupheleleyo kwi-hormone yesini kunye ne-glucocorticoid ngokwemiqathango yomthombo, ukwakheka kweekhemikhali, i-physiology, i-pharmacology kunye neminye imiba, kwaye ayiyi kuvelisa iziphumo zecala le-hormone yesini kunye ne-glucocorticoid. Ihomoni yokukhula yihomoni ye-peptide eveliswa lidlala langaphambili lepituitary lomzimba womntu. Iqulunqwe ngama-amino acids angama-191 kwaye inobunzima bemolekyuli ye-22KD. I-hormone yokukhula idlala umsebenzi wayo we-physiological ngokuvuselela isibindi kunye nezinye izicubu ukuvelisa i-insulin-like growth factor (IGF-1), ukukhuthaza ukukhula kwamathambo, ukukhuthaza i-anabolism yomzimba kunye ne-protein synthesis, ukukhuthaza i-lipolysis, kunye nokuvimbela ukusetyenziswa kwe-glucose. Ngaphambi kokufikisa, ukukhula kunye nophuhliso lomzimba womntu ikakhulu kuxhomekeke kwihomoni yokukhula kunye ne-thyroxine, ukukhula kokufikisa, ukukhula kwehomoni ye-synergistic yesondo, ukukhuthaza ukukhula ngokukhawuleza kobude, ukuba umzimba womntwana uswele ihomoni yokukhula, kuya kubangela ukulibaziseka kokukhula. , ngeli xesha, kufuneka yongeze ihomoni yokukhula yangaphandle.
