I-3D bioprinting iwubuchwepheshe bokukhiqiza obuthuthukisiwe obungakhiqiza ubujamo bezicubu ezihlukile kanye nezakhiwo ngendlela yesendlalelo-nesendlalelo samaseli ashumekiwe, okwenza lokhu kuhlelwa kube maningi amathuba okuthi kubonise ukwakheka kwemvelo kwamangqamuzana amaningi ezakhiwo zemithambo yegazi. Uchungechunge lwama-ink e-hydrogel bio-inks lwethulwe ukuklama lezi zakhiwo; noma kunjalo, ama-bio-inks atholakalayo angalingisa ukwakheka kwemithambo yegazi yezicubu zemvelo anemikhawulo. Ama-bio-inks amanje awanakho ukuphrinta okuphezulu futhi awakwazi ukufaka amaseli aphilayo asondelene kakhulu ezakhiweni eziyinkimbinkimbi ze-3D, ngaleyo ndlela ehlise ukusebenza kahle kwazo.

Ukuze banqobe la maphutha, u-Gaharwar no-Jain bathuthukise i-bio-ink entsha eyenziwe nge-nano-engineered ukuze baphrinte i-3D, imithambo yegazi eningi enembile ngokwemvelo. Indlela yabo ihlinzeka ngesixazululo sesikhathi sangempela esithuthukisiwe se-macrostructures kanye ne-microstructures yezinga lezicubu, okwamanje okungenakwenzeka nge-bio-inks.

Isici esiyingqayizivele kakhulu sale inki ye-nano-engineered bio-ink ukuthi kungakhathaliseki ukuminyana kwamaseli, ibonisa ukuphrinta okuphezulu kanye nekhono lokuvikela amaseli ahlanganisiwe kusuka kumandla aphezulu we-shear ngesikhathi senqubo ye-bioprinting. Kuyaphawuleka ukuthi i-3D bio Amaseli aphrintiwe agcina i-phenotype enempilo futhi ahlala esebenza cishe inyanga ngemva kokukhiqizwa.

Kusetshenziswa lezi zici eziyingqayizivele, ama-bio-inks enziwe nge-nano-engineered aphrintwa emithanjeni yegazi eyi-3D cylindrical, eyakhiwe ngamasiko aphilayo amangqamuzana e-endothelial kanye namaseli emisipha abushelelezi we-vascular, okunikeza abacwaningi ithuba lokulingisa imiphumela yemithambo yegazi kanye nemithambo yegazi. izifo.

Lesi sitsha se-3D bioprinted sinikeza ithuluzi elingaba khona lokuqonda i-pathophysiology yezifo zemithambo yegazi kanye nokuhlola ukwelashwa, ubuthi noma amanye amakhemikhali ezivivinyweni zangaphambi komtholampilo.