Lapho imvelo yonakaliswa, i-biotechnology ingasetshenziswa ukuvikela imvelo emonakalweni wesibili. Ibhayoloji icaciswe kakhulu futhi ingaqeda imithombo yokungcola okukhethekile. Isibonelo, umkhumbi othutha uwoyela ongahluziwe ungcolisa indawo yolwandle ngowoyela omkhulu ngenxa yengozi. Izinhlobo ezikhethekile ze-microbial ezibola uwoyela osindayo zisetshenziselwa ukubola uwoyela osindayo futhi ziwugaye zibe ama-acids amaketanga amafushane amukelekile ukuze kuqedwe ukungcola. Ngaphezu kwalokho, uma inhlabathi ingcoliswe izinsimbi ezisindayo, izitshalo ezithile zingase zisetshenziselwe ukumunca imithombo yokungcola.