I-Wnt yenziwa isebenze ngama-receptors endaweni yeseli, aqala ukusabela okulandelanayo ngaphakathi kweseli. Amasignali amaningi kakhulu noma ambalwa kakhulu angaba yinhlekelele, okwenza kube nzima kakhulu ukufunda le ndlela usebenzisa amasu ajwayelekile ashukumisa ama-receptor angaphezulu kwamaseli.
Ngesikhathi sokukhula kwe-embryonic, i-Wnt ilawula ukuthuthukiswa kwezitho eziningi, njengekhanda, umgogodla, namehlo. Iphinde igcine ama-stem cells kumathishu amaningi kubantu abadala: Nakuba ukusayina kwe-Wnt okunganele kungabangela ukwehluleka ukulungiswa kwezicubu, kungase kuholele ekuboniseni i-Wnt ephakeme kumdlavuza.
Kunzima ukufeza ibhalansi edingekayo ngokusebenzisa izindlela ezijwayelekile zokulawula lezi zindlela, njengokugqugquzela amakhemikhali. Ukuxazulula le nkinga, abacwaningi baklama iphrotheni ye-receptor ukuphendula ukukhanya okuluhlaza okwesibhakabhaka. Ngale ndlela, bangakwazi ukushuna kahle ileveli ye-Wnt ngokulungisa ukushuba nobude besikhathi sokukhanya.
"Ukukhanya njengesu lokwelapha kuye kwasetshenziswa ekwelapheni kwe-photodynamic, okunezinzuzo ze-biocompatibility futhi akukho mphumela osele endaweni eveziwe. Nokho, izindlela eziningi zokwelapha ze-photodynamic ngokuvamile zisebenzisa ukukhanya ukuze zikhiqize amakhemikhali anamandla amakhulu, njengezinhlobo ze-oxygen esebenzayo. Ngaphandle kwalokho, iningi lemithi yokwelapha ye-photodynamic ivame ukusebenzisa ukukhanya ukuze kukhiqizwe amakhemikhali anamandla amakhulu, njengezinhlobo ze-oxygen esebenzayo. Ngaphandle ukuhlukanisa phakathi kwezicubu ezivamile nezicubu ezigulayo, ukwelapha okuhlosiwe kuba yinto engenakwenzeka," kusho u-Zhang: "Emsebenzini wethu, sibonise ukuthi ukukhanya okuluhlaza okwesibhakabhaka kungenza kusebenze izindlela zokubonisa ezingxenyeni ezihlukene zemibungu yesele. ukunciphisa inselelo yobuthi obungahlosiwe."
Abacwaningi babonise ubuchwepheshe babo futhi baqinisekisa ukulungiswa nokuzwela kwayo ngokukhuthaza ukuthuthukiswa komgogodla kanye nekhanda lemibungu yexoxo. Bacabanga ukuthi ubuchwepheshe babo bungase busetshenziswe kwamanye ama-receptors aboshwe ulwelwesi okubonakale kunzima ukukhomba, kanye nezinye izilwane ezabelana ngendlela ye-Wnt, ukuze ziqonde kangcono ukuthi lezi zindlela zilawula kanjani intuthuko nokuthi kwenzekani lapho ziphela.
"Njengoba siqhubeka nokwandisa uhlelo lwethu oluzwela ukukhanya ukuze luhlanganise ezinye izindlela eziyisisekelo zokubonisa izimpawu zokuthuthukiswa kwe-embryonic, sizohlinzeka umphakathi wesayensi yezinto eziphilayo ngeqoqo lamathuluzi abalulekile angabasiza ukuthi banqume imiphumela yesignali ngemuva kwezinqubo eziningi zentuthuko," kusho uYang. .
Abacwaningi banethemba lokuthi ubuchwepheshe obusekelwe ekukhanyeni abasebenzisa ukutadisha i-Wnt bungakhanyisa ukulungiswa kwezicubu kanye nocwaningo lomdlavuza ezicutshini zomuntu.
"Ngenxa yokuthi umdlavuza uvame ukufaka amasiginali asebenze ngokweqile, sibona ngeso lengqondo ukuthi izivuseleli ze-Wnt ezizwela ukukhanya zingasetshenziswa ukutadisha ukuqhubeka komdlavuza kumaseli aphilayo," kusho uZhang. "Kuhlanganiswe ne-imaging cell ephilayo, sizokwazi ukunquma ngobuningi ukuthi yini engashintsha amangqamuzana avamile abe amangqamuzana anomdlavuza. Umkhawulo wesignali unikeza idatha eyinhloko yokuthuthukiswa kokwelashwa okuqondile okuhlosiwe emithini yokunemba esikhathini esizayo."
