Izilondolozi zezokwelapha ezivame ukusetshenziswa ze-hormone yokukhula yi-phenol, i-cresol nokunye. I-Phenol iyisilondolozi esivamile semithi. Ucwaningo olwenziwa yi-United States Environmental Protection Agency (EPA) lubonise ukuthi ukuchayeka ku-phenol kungase kubangele ukukhubazeka komntwana. Kube nezimo zokusetshenziswa esibhedlela kwezibulala-magciwane ze-phenol okuholela ekuqubukeni kwe-hypobilirubinemia yezingane kanye nokufa okuthile kombungu, ngakho-ke i-phenol ithathwa njengobuthi ezinganeni noma ezinganeni.
Ngenxa yobuthi be-phenol, i-FDA, i-EU kanye ne-China zilawule ngokuqinile umkhawulo ophezulu wokwengezwa kwezivimbelakuvunda. I-FDA ibeka ukuthi ukugcwala kwe-phenol kufanele kulawulwe ngaphakathi kwe-0.3%, kodwa i-FDA iphinde ichaze ukuthi ukusabela okubi kakhulu kuye kwabikwa kwezinye iziguli ngisho nalapho kugxilwe khona okuvunyelwe, futhi ukusetshenziswa kwesikhathi eside kufanele kugwenywe. Ukuphuza njalo imithamo ephansi evunyelwe kufanele futhi kugwenywe izinsuku ezingaphezu kweziyi-120. Okusho ukuthi, nakuba ukuhlushwa kwe-phenol okwengezwe ku-hormone yokukhula kuphansi kakhulu, ukusabela kwayo okubi kuvame ukwenzeka ngemva kokusetshenziswa isikhathi eside, futhi ngisho namacala aholela ezifweni angatholakala yonke indawo. Phela, izivimbelakuvunda ziyi-bacteriostatic ngobuthi bazo, futhi uma ubuthi buphansi kakhulu, inhloso ye-bacteriostatic ayisebenzi.
Ngenxa yezidingo eziphakeme zobuchwepheshe ze-ejenti yamanzi ye-hormone yokukhula, abakhiqizi abaningi bamanzi be-hormone yokukhula bangakwazi ukwengeza kuphela izilondolozi ukuze kuqinisekiswe ukuthi i-hormone yokukhula ayiwohloki ngenxa yobuchwepheshe obulinganiselwe bokukhiqiza, kodwa umjovo wesikhathi eside wezivimbelakuvunda uzoletha umonakalo ongaba yingozi isimiso sezinzwa esimaphakathi sezingane, isibindi, izinso nezinye izitho zomzimba. Ngakho-ke, ezigulini ezisebenzisa isikhathi eside i-hormone yokukhula, i-hormone yokukhula ngaphandle kwama-preservatives kufanele ikhethwe ngangokunokwenzeka, ukuze igweme ngokuphumelelayo imiphumela emibi yezidakamizwa ezinobuthi futhi wenze ukusetshenziswa kwesikhathi eside kuphephe ezinganeni.
