I-hormone yokukhula iyisidakamizwa samaprotheni. Njengoba umsebenzi wamaprotheni awukwazi ukunqunywa ngokujwayelekile, izinguquko esakhiweni sendawo samaprotheni, ikakhulukazi ukungafani kwezibopho ze-disulfide, zingathinta umsebenzi wezinto eziphilayo zamaprotheni futhi ngaleyo ndlela zithinte ukusebenza kwezidakamizwa zamaprotheni, futhi umsebenzi othize ungabonisa lesi simo. Umsebenzi othize ubhekisela kuyunithi yomsebenzi webhayoloji ngemiligremu ngayinye yephrotheni, okuyinkomba ebalulekile yemithi yamaprotheni ehlanganisiwe ehlukile emithini yamakhemikhali. Ukutholwa kwezinto ezithile zomsebenzi akukwazi nje ukubonisa ukuzinza kwenqubo yokukhiqiza, kodwa futhi kuqhathanise ikhwalithi yomkhiqizo ofanayo okhiqizwe amasistimu okuveza ahlukene nabakhiqizi abahlukene. Umsebenzi othize ophezulu ubonisa ukuthi ubuchwepheshe bokukhiqiza bomkhiqizo buthuthuke kakhulu, ubumsulwa buphakeme futhi izinga lingcono.

Njengoba i-ejenti ye-hormone yokukhula ivuselela kabusha imikhiqizo emisha, i-ejenti entsha ye-hormone yokukhula yesizukulwane sesibili ayinazo izivimbelakuvunda, hhayi nje kuphela engakwazi ukuxazulula inkinga yomjovo wama-preservatives angeziwe, futhi igwema ukusetshenziswa kokulondoloza i-phenol isikhathi eside kungase kulethe umonakalo we-germ cell DNA. kanye nemizwa emaphakathi kanye nengozi engaba khona yokulimala kwesibindi nezinso, kuyisinqumo esingcono kakhulu sokusebenzisa izidakamizwa eziphephile emtholampilo.