Ososayensi baseMelika bafunde indlela yezinto eziphilayo ngemuva kokushiswa kwamafutha, bahlonza iphrotheni edlala indima ebalulekile ekulawuleni umzimba, futhi bafakazela ukuthi ukuvimbela umsebenzi wayo kungakhuthaza le nqubo kumagundane. Le phrotheni ebizwa ngokuthi i-Them1 ikhiqizwa ngamafutha ensundu womuntu, ihlinzeka ngomkhombandlela omusha kubacwaningi ukuze bathole ukwelashwa okuphumelelayo kokukhuluphala.
Ososayensi abalandela lolu cwaningo olusha bebefunda i-Them1 cishe iminyaka eyishumi, futhi banentshisekelo yokuthi amagundane akhiqiza kanjani inani elikhulu lamaprotheni esicutshini sawo esinsundu se-adipose ngaphansi kwamazinga okushisa abandayo. Ngokungafani nezicubu ze-adipose ezimhlophe ezigcina amandla engeziwe emzimbeni njengama-lipids, izicubu ze-adipose ezinsundu zishiswa ngokushesha ngumzimba ukuze zikhiqize ukushisa lapho kubanda. Ngenxa yalesi sizathu, izifundo eziningi zokulwa nokukhuluphala zigxile emizamweni yokuguqula amafutha amhlophe abe ngamafutha ansundu.
Abacwaningi banethemba lokuthuthukisa izivivinyo ezisuselwe kulezi zifundo zamagundane zakuqala lapho amagundane eshintshwa ngokofuzo ukuze angabi nawo1. Ngenxa yokuthi babecabanga ukuthi i-Them1 isiza amagundane ukuthi akhiqize ukushisa, babelindele ukuthi ukuwakhipha kuzonciphisa amandla awo okwenza kanjalo. Kodwa kuvela ukuthi ngokuphambene nalokho, amagundane angenayo le phrotheni adla amandla amaningi okukhiqiza ama-calories, ukuze empeleni abe kabili kunamagundane avamile, kodwa alahlekelwe isisindo.
Nokho, uma ususa isakhi sofuzo se-Them1, igundane lizokhiqiza ukushisa okwengeziwe, hhayi okuncane.
Ocwaningweni olusanda kushicilelwa, ososayensi baye bahlolisisa izizathu ezibangela lesi simo esingalindelekile. Lokhu kuhilela ukubheka umthelela we-Them1 kumangqamuzana anamafutha ansundu akhule elabhorethri kusetshenziswa isibonakhulu esikhanyayo nama-electron. Lokhu kubonisa ukuthi njengoba amafutha eqala ukusha, ama-molecule e-Them1 abhekana noshintsho lwamakhemikhali, okuwenza asakazeke kulo lonke ingqamuzana.
Omunye wemiphumela yalokhu kusakazeka ukuthi i-mitochondria, eyaziwa ngokuthi i-cell dynamics, kungenzeka ukuthi iguqule ukugcinwa kwamafutha kube amandla. Lapho isikhuthazo sokushiswa kwamafutha sesiphelile, iphrotheni ye-Them1 izophinde ihlele kabusha ngokushesha ibe isakhiwo esiphakathi kwe-mitochondria namafutha, futhi ibeke umkhawulo ekukhiqizweni kwamandla.
Ukucabanga okunokulungiswa okuphezulu kubonisa: Amaprotheni e-Them1 asebenza kuzicubu ze-adipose ensundu, ehlelwe yaba isakhiwo esivimbela ukuvutha kwamandla.
Lolu cwaningo luchaza indlela entsha elawula imetabolism. I-Them1 ihlasela ipayipi lamandla futhi inqamule ukunikezwa kukaphethiloli ku-mitochondria eshisa amandla. Abantu futhi banamafutha ansundu, azokhiqiza i-Them1 eyengeziwe ngaphansi kwezimo ezibandayo, ngakho lokhu okutholakele kungase kube nomthelela ojabulisayo ekwelapheni ukukhuluphala.
