IHLUKANISWA KAKHULU ngemithi ye-MEDICAL POLYPEPTIDE, ama-antibiotic e-peptide, imigomo, ama-peptide e-antimicrobial ezolimo, ama-peptide okuphakelayo, izimonyo zamakhemikhali zansuku zonke, ama-SOYBEAN peptides okudla, ama-CORN peptides, ama-peptide emvubelo, ama-peptide ekhukhamba olwandle.

Ngokombono wokusebenza, ingahlukaniswa ibe i-peptide ye-antihypertensive, i-peptide ye-antioxidant, i-cholesterol-ehlisa i-peptide, i-peptide esebenzayo ye-opioid, i-oligopeptide ephezulu ye-F-value, i-peptide yokunambitheka kokudla nokunye.

I-peptide esebenzayo, enomsoco, i-hormone, i-enzyme inhibition, ukulawulwa kwamasosha omzimba, i-antibacterial, i-antiviral, i-antioxidant inobudlelwane obuseduze kakhulu. Ama-peptide ngokuvamile ahlukaniswe: izidakamizwa ze-peptide kanye nemikhiqizo yezempilo ye-peptide. Imithi yendabuko ye-peptide ikakhulukazi amahomoni e-peptide. Ukwakhiwa kwemithi ye-peptide kuye kwathuthukiswa emikhakheni eyahlukene yokuvimbela nokulawula izifo, ikakhulukazi kule mikhakha elandelayo.

I-anti-tumor polypeptide

I-Tumorigenesis ingumphumela wezinto eziningi, kodwa ekugcineni ihilela ukulawulwa kwe-oncogene expression. Izakhi zofuzo eziningi ezihlobene nesimila kanye nezici zokulawula zitholwe ngo-2013. Ukuhlola ama-peptide abopha ngokuqondile lezi zakhi zofuzo nezici zokulawula sekuphenduke indawo entsha ekusesheni izidakamizwa ezilwa nomdlavuza. Isibonelo, i-somatostatin isetshenziselwe ukwelapha izimila ze-endocrine zesistimu yokugaya ukudla; Abacwaningi baseMelika bathola i-hexapeptide engavimbela kakhulu i-adenocarcinoma ku-vivo; Ososayensi baseSwitzerland bathole i-octapeptide eyenza i-apoptosis kumaseli wesimila.

I-Antiviral polypeptide

Ngokubophezela kuma-receptors athile kumaseli aphethe, amagciwane akhanga amaseli futhi athembele kuma-protease awo athile ukuze kucutshungulwe amaprotheni kanye nokuphindaphinda kwe-nucleic acid. Ngakho-ke, ama-peptide abophezela kuma-cell receptors noma amasayithi asebenzayo njengama-viral proteases angahlolwa kumtapo wezincwadi we-peptide ukuze athole ukwelashwa kwe-antiviral. Ngo-2013, iCanada, i-Italy namanye amazwe ahlole ama-peptide amaningi amancane anokumelana nezifo kumtapo wezincwadi we-peptide, futhi amanye awo angena esigabeni sokuhlolwa kwemitholampilo. Ngo-June 2004, i-Institute of Microbiology, i-Chinese Academy of Sciences yabika ukuthi isiqondiso esibalulekile solwazi olusha lwephrojekthi eyenziwa yi-Institute of Microbiology, i-Chinese Academy of Sciences, "Ucwaningo ngomshini we-SARS-CoV cell fusion kanye ne-Fusion inhibitors", esenziwe ngokuhlanganyela yi-Institute of Microbiology, Chinese Academy of Sciences kanye neCentre for Modern Virology, Life Sciences, Wuhan University, senze inqubekelaphambili ebonakalayo. Ukuhlola kufakazele ukuthi i-peptide eklanyelwe i-HR2 inganqanda ngempumelelo ukutheleleka kwamaseli akhulisiwe yigciwane le-SARS, futhi ukugxila okusebenzayo kokuvimbela kusekuhlanganiseni kwama-nmoles amaningana. Kuye kwenziwa inqubekelaphambili ebalulekile ekuhlolweni kokuvimbela ukutheleleka ngegciwane kwe-peptide ehlanganisiwe neveziwe ye-HR1 kanye nokuhlolwa okubophezela kwe-in vitro kwe-HR1 ne-HR2. Imithi ye-peptide eyakhelwe ukuvimbela ukuhlanganiswa kwegciwane le-SARS ingavimbela ukutheleleka kwegciwane futhi, esimweni seziguli ezithelelekile, ivimbele ukusakazeka okuqhubekayo kwegciwane emzimbeni. Umuthi we-polypeptide unemisebenzi yokuvimbela kanye nokwelapha. Abacwaningi e-Cell Engineering Research Centre yase-Fourth Military Medical University baye bahlanganisa ama-peptide ayisishiyagalolunye angavimbela ngempumelelo futhi avimbele ukuhlasela kwegciwane le-SARS kumaseli.

Ama-cytokines alingisa ama-peptide

Ukusetshenziswa kwama-receptors ama-cytokines aziwayo ukuze kuhlolwe ama-cytokine alingisa emitapo yolwazi ye-peptide sekuphenduke indawo yocwaningo ngo-2011. Ukuhlolwa kwabantu phesheya i-erythropoietin, abantu bakhulisa i-hormone yeplatelet, i-hormone yokukhula, isici sokukhula kwezinzwa kanye nokuthi izici ezihlukahlukene zokukhula ezifana ne-interleukin - I-peptide yokulingisa engu-1, ukulingisa ukulandelana kwe-amino acid ye-peptide kanye nesici sayo seseli ehambisanayo kuhlukile, ukulandelana kwama-amino acid kodwa kunomsebenzi wama-cytokines, futhi kunezinzuzo zama-amino acid amancane.isisindo samangqamuzana. Ngo-2013 lawa ma-peptide alingisa ama-cytokine angaphansi kophenyo lwangaphambi komtholampilo noma lomtholampilo.

I-peptide esebenzayo ye-antibacterial

Lapho izinambuzane zikhuthazwa indawo yangaphandle, inani elikhulu lama-peptide e-cationic anomsebenzi we-antibacterial akhiqizwa. Ngo-2013, izinhlobo ezingaphezu kwe-100 zama-peptide e-antimicrobial ziye zahlolwa. Ukuhlolwa kwe-in vitro kanye ne-in vivo kuye kwaqinisekisa ukuthi ama-peptide amaningi e-antimicrobial awanawo amandla aqinile e-antibacterial kanye ne-bactericidal, kodwa futhi angabulala amaseli wesimila.

Umuthi wokugomela i-Peptide

Imithi yokugomela i-peptide kanye ne-nucleic acid kwakungenye yezinto ezibaluleke kakhulu emkhakheni wocwaningo lokugoma ngo-2013. Ucwaningo oluningi nokuthuthukiswa kwemigomo ye-viral peptide lwenziwa emhlabeni ngo-2013. imiphumela yokuhlolwa komtholampilo yezinhlobo ezimbili zemithi yokugomela i-HIV-I virus peptide ezifundweni zabantu; I-polypeptide yahlolwa kuprotheni ye-membrane yangaphandle engu-E2 yegciwane le-hepatitis C (HCV), engashukumisa umzimba ukuba ukhiqize amasosha omzimba avikelayo. I-United States ithuthukisa umuthi wokugoma we-malaria polyvalent antigen polypeptide; Umuthi wokugomela i-human papillomavirus peptide womdlavuza womlomo wesibeletho usungene ezivivinyweni zomtholampilo zesigaba II. I-China futhi yenze umsebenzi omningi ocwaningweni lwemithi yokugomela i-polypeptide eyahlukene.

Ama-peptide okuxilongwa

Ukusetshenziswa okuyinhloko kwama-peptide kuma-reagents okuxilongwa njengama-antigen, amasosha omzimba okuthola izinto eziphilayo ezihambisanayo ze-pathogenic. Ama-antigen e-Polypeptide acacile kakhulu kunama-antigen amaprotheni emvelo amagciwane amancane noma amagciwane futhi kulula ukuwalungiselela. Ama-reagents okuthola ama-antibody ahlanganiswe nama-antigen e-polypeptide ngo-2013 ahlanganisa: A, B, C, G igciwane lesifo sesibindi, i-HIV, i-cytomegalovirus yomuntu, i-herpes simplex virus, igciwane le-rubella, i-Treponema pallidum, i-cysticercosis, i-trypanosoma, isifo se-Lyme kanye nama-reagents okuthola i-rheumatoid. Iningi lama-antigen e-peptide asetshenzisiwe atholakala kuphrotheni yendabuko yomzimba ohambisana ne-pathogenic, kanti amanye bekungama-peptide amasha ngokuphelele atholwe kumtapo wezincwadi we-peptide.