Isingeniso se-MGF:
I-Mechano Growth Factor Mechano Growth Factor, evame ukubizwa ngokuthi i-MGF, iyinhlobonhlobo ye-splice ye-IGF-1, isici sokukhula/sokulungisa esitholakala ekuzilolongeni noma ezilimele izicubu zemisipha, Kwenza kube nzima ukukhomba ezinye izinhlobo ze-IGF.
Okwenza i-MGF ikhetheke indima yayo eyingqayizivele ekukhuleni kwemisipha. I-MGF inekhono eliyingqayizivele lokuyenga ukukhula kwezicubu ezimoshayo kanye nokwenza ngcono ngokuvula amangqamuzana e-muscle stem nokwandisa ukulawulwa kokuhlanganiswa kwamaprotheni. Leli khono eliyingqayizivele lithuthukisa ngokushesha ukululama futhi lisheshisa ukukhula kwemisipha. Ngaphandle kwesizinda se-receptor ye-IGF-1, i-MGF iphinde iqalise ukusebenza kwe-cell satellite ye-muscle (stem cell), ngaleyo ndlela ikhulise inzuzo ye-protein synthesis; Ngakho-ke, uma isetshenziswe kahle, ingathuthukisa kakhulu imisipha yemisipha.
I-IGF-1 iyi-hormone ye-70-amino acid enesakhiwo esifana ne-insulin ekhishwa isibindi, futhi ukukhishwa kwe-IGF-1 kuthonywa ukukhishwa nokukhululwa kwe-hormone yokukhula (GH) emzimbeni. I-IGF-1 ithinta cishe wonke amangqamuzana emzimbeni, ikakhulukazi ngoba ihileleke ekulungiseni iseli. Lapho izicubu zemisipha zonakalisiwe, lokhu kudala ukusabela emzimbeni okubizwa ngokuthi i-T
I-IGF-1 ihlukaniswe yaba izinhlobo ezimbili, i-IGF-1Ec ne-IGF-1Ea, eyokuqala i-MGF.
Izinhlobonhlobo ze-MGF zokuhlanganisa ama-IGF amabili akhiqizwa isibindi:
Esokuqala yi-IGF-1EC: lesi yisigaba sokuqala sokukhulula i-igf splicing variant, futhi sizokwenza
Ivuselela ukusebenza kweseli yesathelayithi
Eyesibili i-Hepatic IGF-IEA: Lokhu ukukhululwa kwesibili kwe-igf esibindini, futhi izinzuzo zayo ze-anabolic zincane kakhulu kunezokuqala.
I-MGF ihluke kweyesibili, i-IGF-IEa, ngoba inokulandelana kwe-peptide ehlukile futhi inesibopho sokugcwalisa amaseli esathelayithi kumisipha yamathambo; Ngamanye amazwi, inikeza izinzuzo eziningi ze-anabolic nemiphumela emide kunohlelo lwesibili lwe-MGF ehlukile kwesibindi.
Ngakho-ke kufanele ucabange nge-MGF njengokuhluka okuthuthukisiwe kwe-igf ngokwezinzuzo ze-anabolic. Ngemva kokuqeqeshwa, i-IGF-I gene splices MGF bese ibangela hypertrophy kanye nokulungiswa kokulimala kwemisipha yendawo ngokwenza kusebenze amangqamuzana omile emisipha nezinye izinqubo ezibalulekile ze-anabolic (kuhlanganise namaprotheni synthesis echazwe ngenhla) nokwandisa ukugcinwa kwe-nitrogen emisipha.
Kumagundane, ezinye izifundo zibonise ukwanda kwe-20% kwesisindo somzimba ngomjovo owodwa we-MGF, kodwa ngicabanga ukuthi eziningi zalezi zifundo azinembile, kodwa amandla e-MGF awanakuphikwa.
Ukuhlanganiswa kwe-MGF kwenza amaseli e-satellite asebenze, okuholela ekukhuleni kwemicu emisha yemisipha emzimbeni. Ngaphezu kwalokho, ukuba khona kwe-MGF kwandisa izinga lokuhlanganiswa kwamaprotheni omzimba, ngaleyo ndlela kukhuthaze i-myohypertrophy nokwandisa! Khula! Khula! Yebo kubaluleke kakhulu ukulungisa i-196 ekhona
Kunjalo, izici zokululama ezihlobene ne-MGF ngokungangabazeki ziyindawo ekhanga kakhulu ye-MGF.
Nakuba ukusebenza kwe-MGF kungase kubonakale kuyindida ekuqaleni, inqubo ngokwayo iba lula uma uyibheka isinyathelo ngesinyathelo:
I-1.IGF-1 ikhishwa ngokuzivocavoca (kwenzeka ngemva kokuzivocavoca)
2. Hlanganisa i-IGF-1 ne-MGF
I-3.MGF ivuselela ukubuyiswa kwezicubu ze-muscle ngemuva kokulimala kokuqeqeshwa ngokuvula amaseli e-muscle stem
Ukusetshenziswa kwe-MGF
Kwenzekani emisipha yakho lapho uziqeqesha? Adiliza, amaseli alimele, izicubu zemisipha zidinga ukulungiswa, futhi umzimba wakho ukhiqiza izinhlobo ezimbili ze-MGF splicing variants. Ukukhululwa kokuqala kwesibindi esingu-1 okuhlukile ngenhla kusiza ukubuyiswa kwamaseli emisipha. Kuthiwani uma i-MGF ingekho? Kalula nje, amangqamuzana emisipha awalungisi futhi afe. Amaseli emisipha amangqamuzana avuthiwe angakwazi ukuhlukana, amangqamuzana emisipha atholakala kuma-stem cells ahlukana abe amangqamuzana emisipha ngokusebenzisa i-mitosis, ngakho umzimba awukwazi ukulungisa izicubu ngokushintshwa kwamangqamuzana ngemva kokulimala kwemisipha, ungalungisa kuphela amangqamuzana okuqala, uma amaseli awalungiswa, azofa. Imisipha yakho izoba mincanefuthi buthaka. Ngokusebenzisa i-MGF, ukutakula komzimba kungasheshiswa futhi amangqamuzana ezicubu zemisipha angandiswa ngokuvuselela ukuvuthwa okugcwele kwamaseli wesathelayithi. Mayelana nomthamo, i-200mcg umjovo wendawo yamazwe amabili iyona engcono kakhulu (umjovo wendawo uyadingeka ku-MGF). Inkinga kuphela nge-MGF ukuthi isigamu-ukuphila kwayo kufushane kakhulu, imizuzu engu-5-7 kuphela, futhi idinga ukusetshenziswa ngokushesha ngemva kokuqeqeshwa ukuze uthole imiphumela engcono kakhulu, kuyilapho abantu abaningi bengenaso isikhathi sokuyisebenzisa phakathi naleli windi. ngemva kokuqeqeshwa.
Iyini i-PEG-MGF?
Njengoba kushiwo ngenhla, i-drawback enkulu ye-MGF isikhathi sayo esifushane somsebenzi, ngakho-ke inguqulo esebenza isikhathi eside ye-MGF, PEG MGF, yenziwe. Ngokungeza i-PEG(i-polyethylene glycol, isithako esingenabuthi) ku-MGF, uhhafu wempilo ye-MGF ungandiswa usuka emaminithini uye emahoreni. Isikhathi esinwetshiwe somsebenzi sisho ukuthi ukusebenziseka kwayo nokuguquguquka kuzothuthukiswa kakhulu, futhi i-PEG MGF inomphumela wesistimu lapho umsipha wonakalisiwe noma unesifo, kunokuba ulinganiselwe iphuzu elilodwa.
Ngisebenzisa kanjani i-PEG-MGF
Indawo elandelayo okudingeka sigxile kuyo ukuthi singazuza kanjani ngokugcwele enguqulweni ye-MGF ethathe isikhathi eside. Uma imisipha yakho ilimele, umzimba wakho ukhulula ama-pulses we-MGF clip-on variant echazwe ngenhla, elandelwa ifomu elisebenza isikhathi eside elisuka esibindini elinezinzuzo eziphansi ze-anabolic. Ngakho-ke kubonakala kuwukumosha ukujova i-MGF kuleli phuzu, ngoba wenza buthaka ukukhululwa komzimba, ungakuthuthukisi. Ngakho-ke, ukusebenzisa i-PEG MGF ngezinsuku zokungazivocavoci empeleni kuyindlela engcono kakhulu. Ngenxa yokulimala kwemisipha, i-MGF inama-receptors amaningi, futhi imiphumela yayo ihlelekile. Ngokwandisa ukugcinwa kwe-nitrogen, ukuguqulwa kwamaprotheni kanye nokusebenza kwe-satellite cell, kuzosiza ukubuyisela yonke imisipha. Ngokwenza kanjalo, ukhulisa ubude besikhathi osithathayo ukulungisa izicubu zomzimba kanye nezindlela zokukhula. Ukusebenzisa i-PEG MGF ngokuhlanganyela ne-IGF iphelele, kodwa ngenxa yokuhlangana okuqinile kokwamukela kwe-IGF, uma usebenzisa kokubili i-IGF-1 ne-PEG MGF, ukusebenza kahle kwe-MGF kuzoncishiswa.
Iziphakamiso zami zimi kanje:
I-IGF DES noma IGF1-LR3 isetshenziswa ngezinsuku zokuqeqeshwa ngaphambi kokuqeqeshwa, okungakhinyabezi ukukhululwa kwe-MGF esibindini somzimba. I-IGF-DES yasetshenziselwa ukuthuthukisa ngokushesha indawo eshiywe yisikhathi, bese i-MGF ye-200-400 MCG yasetshenziswa ngakusasa ukwandisa indlela yokululama nokukhula. I-synergy ephelele.
Isitoreji se-PEG MGF
I-MGF ingagcinwa esiqandisini kuze kube yizinyanga eziyisithupha. Gwema ukuchayeka ekushiseni noma elangeni
Ngaphansi kokukhanya.
