I-hormone yokukhula komuntu (i-hGH) i-hormone ye-endocrine ekhiqizwa futhi igcinwe yi-anterior pituitary gland. I-hGH ingakhuthaza ukwakheka kwe-articular cartilage kanye nokukhula kwe-epiphyseal cartilage ngokusebenzisa i-hormone ye-intergrowth, ebaluleke kakhulu ekukhuleni komuntu. Ibuye iqondiswe ngamanye amahomoni akhiqizwa yi-hypothalamus. Uma ukuntula kwe-hGH kungabangela ukuphazamiseka kokukhula komzimba, okuholela ekubeni nesiqu esifushane. Imfihlo ye-hGH ifihliwe ekujikelezeni ngendlela ye-pulse, futhi kunzima ukubona i-HGH egazini lapho isendleleni yokuphuma. Kuyanda ngesikhathi sendlala, ukuzivocavoca nokulala. I-pituitary gland ye-fetus yomuntu iqala ukukhipha i-hGH ekupheleni kwenyanga yesithathu, futhi izinga le-serum hGH le-fetus likhuphuka kakhulu, kodwa izinga le-serum hGH lezingane ezisanda kuzalwa zesikhathi esigcwele liphansi, bese izinga lokuphuma likhuphuka isigaba sobuntwana, futhi sifinyelela umvuthwandaba wobusha, futhi izinga lokuphuma kwe-hGH liyehla kancane kancane kubantu abadala abangaphezu kweminyaka engama-30 ubudala. Abantu abavamile badinga i-hGH yokukhula kwe-longitudinal, futhi izingane ezinokuntuleka kwe-hGH zifushane ngomzimba.

Ngo-1958, uRaben waqala wabika ukuthi ukukhula kwezicubu zeziguli ezine-hypophysial dwarf kwaba ngcono kakhulu ngemva kokujova i-pituitary extract yomuntu. Nokho, ngaleso sikhathi, okuwukuphela komthombo we-hGH kwakuyindlala ye-adenohypophysial yomuntu yokuhlolwa kwesidumbu, futhi inani le-hGH elingasetshenziselwa isicelo somtholampilo lalilinganiselwe kakhulu. Izindlala ze-adenohypophysial ezingaba ngu-50 kuphela ezanele ukukhipha umthamo we-HGH odingwa isiguli esisodwa unyaka owodwa wokwelashwa. Amanye amahomoni e-pituitary nawo angangcoliswa ngenxa yezindlela zokuhlanza. Ngokuthuthukiswa kwesayensi nobuchwepheshe, manje kungenzeka ukukhiqiza i-hormone yokukhula komuntu ngobunjiniyela bezakhi zofuzo. I-hGH ekhiqizwa ngale ndlela inesakhiwo esifanayo ne-hGH emzimbeni womuntu ngokuhlanzeka okuphezulu kanye nemiphumela emibi embalwa. Ngenxa yemithombo eningi yezidakamizwa, akuzona kuphela izingane ezine-GHD ye-pituitary ezingelashwa, kodwa futhi nokwelashwa kwesimo esifushane okubangelwa ezinye izizathu.

Ukusebenzisa i-hormone yokukhula ukuze uphathe ubude obufushane, umgomo uwukuvumela ingane ukuba ibambe, igcine izinga elivamile lokukhula, ithole ithuba lokuthomba ngokushesha, futhi ekugcineni ifinyelele ukuphakama komuntu omdala. Umkhuba womtholampilo wesikhathi eside ufakazele ukuthi i-hormone yokukhula iyisidakamizwa sokwelapha esiphephile nesisebenzayo, futhi lapho kuqala ukwelashwa, kuba ngcono umphumela wokwelashwa.

Nakuba i-hormone yokukhula ibizwa nangokuthi i-hormone, ihluke ngokuphelele ku-hormone yocansi kanye ne-glucocorticoid mayelana nomthombo, isakhiwo samakhemikhali, i-physiology, i-pharmacology nezinye izici, futhi ngeke ikhiqize imiphumela emibi ye-hormone yocansi kanye ne-glucocorticoid. I-hormone yokukhula i-peptide hormone ekhiqizwa indlala yangaphambili ye-pituitary yomzimba womuntu. Yakhiwe ngama-amino acid ayi-191 futhi inesisindo samangqamuzana angama-22KD. I-hormone yokukhula idlala umsebenzi wayo wokuphila ngokuvuselela isibindi nezinye izicubu ukuze zikhiqize i-insulin-like growth factor (IGF-1), ikhuthaze ukukhula kwamathambo, ikhuthaze i-anabolism yomzimba kanye nokuhlanganiswa kwamaprotheni, ikhuthaze i-lipolysis, futhi ivimbele ukusetshenziswa kwe-glucose. Ngaphambi kokuthomba, ukukhula nokuthuthukiswa komzimba womuntu kuncike ikakhulukazi ku-hormone yokukhula kanye ne-thyroxine, ukuthuthukiswa kokuthomba, i-hormone yokukhula ye-synergistic sex hormone, iphinde ikhuthaze ukukhula okusheshayo kobude, uma umzimba wengane untula i-hormone yokukhula, kuzodala ukubambezeleka kokukhula. , ngalesi sikhathi, idinga ukwengeza i-hormone yokukhula yangaphandle.