Emzimbeni womuntu, i-metabolism yamandla incike ikakhulukazi kumjikelezo we-tricarboxylic acid, esebenzisa i-D-glucose njengento yamandla. Ekuziphendukeleni kwemvelo kwesikhathi eside, umzimba womuntu wenze uhlelo lwebhayoloji oluyinkimbinkimbi noluqondile olubona futhi lugaye ama-molecule eglucose. Ngokuthuthuka kwezinga lokuphila kwabantu, isifo sikashukela, "umbulali othule", sibeke engcupheni impilo yabantu futhi silethe umthwalo osindayo wezomnotho emphakathini. Amazinga eglucose egazi ajwayelekile kanye nemijovo ye-insulin kuletha ukungakhululeki ezigulini. Kukhona futhi izingozi ezingaba khona njengobunzima bokulawula umthamo womjovo kanye nokusabalala kwezifo zegazi. Ngakho-ke, ukuthuthukiswa kwama-bionic biomatadium ukuze kukhishwe i-insulin elawulwa ngobuhlakani iyisixazululo esifanelekile sokuthola ukulawulwa kwesikhathi eside kwamazinga eglucose egazini ezigulini ezinesifo sikashukela.
Kunezinhlobo eziningi ze-glucose isomers kukho kokubili ukudla noketshezi lomzimba lomzimba womuntu. Ama-enzyme e-biological womzimba womuntu angakwazi ukubona ngokunembile ama-molecule e-glucose futhi abe nezinga eliphakeme lokucaciswa. Kodwa-ke, i-synthetic chemistry inokubona okuthile kwama-molecule e-glucose. Isakhiwo sinzima kakhulu. Lokhu kungenxa yokuthi ukwakheka kwamangqamuzana ama-molecule e-glucose nama-isomers awo (afana ne-galactose, i-fructose, njll.) afana kakhulu, futhi aneqembu elilodwa elisebenzayo le-hydroxyl, okunzima ukulibona ngokunembile ngamakhemikhali. Ama-ligand amakhemikhali ambalwa okuye kwabikwa ukuthi anekhono lokuqaphela i-glucose cishe wonke anezinkinga ezifana nenqubo yokuhlanganisa eyinkimbinkimbi.
Muva nje, ithimba likaSolwazi u-Yongmei Chen kanye noSolwazi Ozakanye u-Wang Renqi we-Shaanxi University of Science and Technology bahlanganyele no-Associate Professor Mei Yingwu wase-Zhengzhou University ukuze badizayine uhlobo olusha olusekelwe kusistimu ye-bidentate-β- Hydrogel ye-cyclodextrin. Ngokwethula ngokuqondile iqembu le-phenylboronic acid esikhundleni se-2,6-dimethyl-β-cyclodextrin (DMβCD), i-molecular slit ehambisana nesakhiwo se-topological ye-D-glucose iyakhiwa, engahlanganiswa ngokuqondile nama-molecule e-D-Glucose. kanye nokukhulula ama-proton, okwenza i-hydrogel ivuvuke, ngaleyo ndlela ibangele ukuthi i-insulin elayishwe ngaphambili ku-hydrogel ikhishwe ngokushesha endaweni yegazi. Ukulungiswa kwe-bidentate-β-cyclodextrin kudinga kuphela izinyathelo ezintathu zokusabela, akudingi izimo ezinzima zokuhlanganiswa, futhi isivuno sokusabela siphezulu. I-hydrogel elayishwe i-bidentate-β-cyclodextrin isabela ngokushesha ku-hyperglycemia futhi ikhiphe i-insulin ohlotsheni lwamagundane esifo sikashukela, esingafinyelela ukulawula isikhathi eside kwamazinga kashukela egazini phakathi namahora ayi-12.
