3D bioprinting yog ib qho kev tsim khoom siv thev naus laus zis uas tuaj yeem tsim cov ntaub so ntswg tshwj xeeb thiab cov qauv hauv txheej txheej txheej ntawm cov hlwb, ua rau qhov kev npaj no muaj feem cuam tshuam txog cov txheej txheem ntau lub cev ntawm cov hlab ntsha. Ib series ntawm hydrogel bio-inks tau qhia los tsim cov qauv no; Txawm li cas los xij, cov khoom siv bio-inks uas tuaj yeem ua raws li cov txheej txheem ntawm cov hlab ntsha hauv cov hlab ntsha muaj kev txwv. Tam sim no bio-inks tsis muaj peev xwm luam tawm tau zoo thiab tsis tuaj yeem tso cov hlwb nyob hauv cov txheej txheem 3D nyuaj, yog li txo lawv cov txiaj ntsig.

Txhawm rau kov yeej cov kev tsis txaus no, Gaharwar thiab Jain tau tsim ib qho tshiab nano-engineered bio-ink los luam 3D, anatomically raug ntau cov hlab ntsha. Lawv txoj kev muab kev daws teeb meem ntawm lub sijhawm tiag tiag rau macrostructures thiab cov ntaub so ntswg-theem microstructures, uas tam sim no tsis tuaj yeem ua tau nrog bio-inks.

Ib tug tshwj xeeb feature ntawm no nano-engineered bio-ink yog hais tias txawm lub cell ceev, nws nthuav tawm siab printability thiab muaj peev xwm los tiv thaiv encapsulated hlwb los ntawm siab shear rog thaum lub sij hawm bioprinting. Nws yog ib qho tsim nyog sau cia tias 3D bio Cov ntaub ntawv luam tawm muaj kev noj qab haus huv phenotype thiab nyob twj ywm rau ze li ib hlis tom qab tsim khoom.

Siv cov yam ntxwv tshwj xeeb no, nano-engineered bio-inks tau luam tawm rau hauv 3D cylindrical cov hlab ntsha, uas yog tsim los ntawm kev sib koom ua ke ntawm cov hlwb endothelial thiab vascular du leeg hlwb, uas muab cov kws tshawb fawb nrog lub sijhawm los simulate cov teebmeem ntawm cov hlab ntsha thiab kab mob.

Lub thawv 3D bioprinted no muab lub peev xwm rau kev nkag siab txog pathophysiology ntawm cov kab mob vascular thiab ntsuas kev kho mob, co toxins lossis lwm yam tshuaj hauv kev sim ua ntej.