Lub peptide ua haujlwm li cas? Vim li cas koj thiaj xav tau peptides?

 KNOWLEDGE    |      2023-03-28

Vim tias los ntawm lub tswv yim ntawm cov protein, txhua lub cell hauv lub cev thiab tag nrho cov khoom tseem ceeb muaj cov proteins koom nrog. Protein suav rau 16% ~ 20% ntawm qhov hnyav ntawm tib neeg lub cev. Muaj ntau hom protein ntau hauv tib neeg lub cev, nrog rau cov khoom sib txawv thiab kev ua haujlwm, tab sis tag nrho cov ntawm lawv yog tsim los ntawm 20 hom Amino acid nyob rau hauv sib txawv proportions, thiab lawv tas li metabolized thiab rov ua dua tshiab hauv lub cev.

Cov 20 amino acids hauv tib neeg lub cev tuaj yeem sib xyaw ua ke hauv 2,020 peptides, uas yog tus lej loj heev. Raws li qhov yooj yim pom tias cov qauv lom neeg txiav txim siab ua haujlwm, lub hauv paus ntsiab lus ntawm txhua tus nquag peptide yog qhov nyuaj heev. Xws li tshuaj tua kab mob tiv thaiv kab mob peptide, tiv thaiv kab mob peptide hauv thymosin.


Antibacterial anti-inflammatory peptide: antibacterial anti-inflammatory peptide (C-L) → zoo nqi → kev ua ntawm cov kab mob cell membrane → nyob rau hauv cov kab mob (xws li Escherichia coli) cell membrane drilling → intracellular khoom to → kab mob tuag, uas yog, tua kab mob; Nyob rau tib lub sijhawm, nws tuaj yeem cuam tshuam endotoxin → txo qhov mob tshwm sim los ntawm LPS.

Thymosin ntawm immunomodulatory peptides tuaj yeem txhim kho kev tiv thaiv kab mob los ntawm kev ua kom muaj kev loj hlob thiab kev loj hlob ntawm T lymphocyte subsets, txhim kho phagocytosis muaj peev xwm ntawm macrophages thiab nce qib kev qhia ntawm interleukin. Calf thymosin, raws li peb feem ntau hu nws, feem ntau ua rau T-lymphocyte system los txhim kho lub cev tiv thaiv kab mob hauv lub cev thiab txhim kho cov kab mob.

Il-6 yog ib qho pleiotropic, uas tuaj yeem tswj kev loj hlob thiab kev sib txawv ntawm ntau lub hlwb, tswj kev tiv thaiv kab mob, cov lus teb rau theem mob thiab hematopoietic muaj nuj nqi, thiab ua lub luag haujlwm tseem ceeb hauv lub cev tiv thaiv kab mob tiv thaiv kab mob.


LTA tuaj yeem txhim kho kev tiv thaiv kab mob los ntawm kev khi TLR4 / MD2 complex → ua kom muaj NF-кB signaling pathway → phagocytosis kev ua ntawm ↑T lymphocytes thiab macrophages thiab tiv thaiv kab mob (xws li TNF-α, IL-6, IL-1β, thiab lwm yam).

Cov neeg sib txawv lub cev lub cev tsis zoo ib yam, yuav ua rau cov nyhuv ntawm kev noj cov peptide tsis zoo ib yam, xws li noj tib lub pluas noj ib txhia neeg noj ntau rog, qee cov neeg tsis noj rog.


Hais txog lub hnub nyoog, cov nyhuv ntawm cov neeg laus feem ntau zoo dua cov hluas; Los ntawm kev noj qab haus huv, cov neeg mob noj cov nyhuv peptide. Ib tug neeg noj qab nyob zoo. Hais txog kev qaug zog, cov neeg qaug zog ua tau zoo dua li lwm tus; Cov neeg uas tau phais tau zoo dua nrog peptides dua li cov neeg uas tsis tau phais ...


Vim peptides muaj cov khoom noj muaj txiaj ntsig zoo, yooj yim nqus, txo lub nra ntawm lub plab zom mov, txhawb lub qhov txhab kho thiab tiv thaiv kev qaug zog, yog li nws yog tib yam li cov tshuaj zoo, thaum tib neeg nyob hauv lub cev, lawv xav tau peptides nrog sib txawv. muaj nuj nqi kom ntxiv.

Nrog rau kev loj hlob ntawm tib neeg, cov neeg niaj hnub no tau ntsib ntau yam teeb meem ntsig txog kev txo qis peptides. Piv txwv li, tshuaj chiv thiab tshuaj tua kab tshem tawm cov enzymes uas degrade proteins hauv cov zaub mov thiab txo cov exogenous enzymes. Niaj hnub nimno ib puag ncig vim huab cua paug, dej thiab av ua paug, poob los yog inactivation ntawm enzymes nyob rau hauv tib neeg lub cev, lub peev xwm ntawm tib neeg lub cev rau degrade proteins yog tsis muaj zog, digestion thiab degradation tsis tuaj yeem nqa tawm ib txwm, qhov tshwm sim ntawm tau txais peptides yog. txo qis, yog li tib neeg lub cev tsis muaj peptides; Cov hluav taws xob niaj hnub no ua rau tib neeg lub cev tiv thaiv kab mob qis, muaj peev xwm zom thiab degrade cov proteins yog inhibited, lub cev nqus dej tsis tuaj yeem nqus cov protein ntau, thiab qhov tshwm sim ntawm kev tau txais peptides raug txo.


Peptide deficiency tau dhau los ua ib qho teeb meem tshwm sim vim qhov loj ntawm kev puas tsuaj thiab poob ntawm peptides hauv tib neeg lub cev. Thaum tib neeg lub cev muaj peev xwm los ua ke peptides tsis muaj zog heev, tib neeg lub cev tsis tuaj yeem ntxiv peptides hauv lub sijhawm, yog li nws yuav tsum tau noj tshuaj kom tau raws li qhov xav tau ntawm tib neeg lub cev.