Nws tau muab faib ua MEDICAL POLYPEPTIDE tshuaj, tshuaj tua kab mob peptide, tshuaj tiv thaiv, tshuaj tua kab mob ua liaj ua teb, pub peptides, tshuaj pleev ib ce txhua hnub, SOYBEAN peptides rau zaub mov, CORN peptides, poov xab peptides, hiav txwv dib peptides.
Los ntawm kev ua haujlwm ntawm qhov pom, nws tuaj yeem muab faib ua cov tshuaj tiv thaiv kab mob peptide, antioxidant peptide, cholesterol-txo peptide, opioid active peptide, siab F-value oligopeptide, zaub mov tsw peptide thiab lwm yam.
Active peptide, nrog rau kev noj haus, tshuaj hormones, enzyme inhibition, tswj kev tiv thaiv kab mob, tshuaj tua kab mob, tshuaj tua kab mob, antioxidant muaj kev sib raug zoo heev. Peptides feem ntau muab faib ua: tshuaj peptide thiab peptide cov khoom noj qab haus huv. Traditional peptide tshuaj yog cov tshuaj hormones peptide. Txoj kev loj hlob ntawm cov tshuaj peptide tau tsim nyob rau hauv ntau yam kev tiv thaiv kab mob thiab kev tswj hwm, tshwj xeeb tshaj yog nyob rau hauv cov nram qab no.
Anti-tumor polypeptide
Tumorigenesis yog tshwm sim los ntawm ntau yam, tab sis thaum kawg suav nrog kev tswj hwm ntawm oncogene qhia. Ntau cov noob caj noob ces thiab cov kev tswj hwm tau pom nyob rau hauv 2013. Kev tshuaj xyuas peptides uas khi tshwj xeeb rau cov noob no thiab cov txheej txheem tswj hwm tau dhau los ua qhov chaw tshiab hauv kev tshawb nrhiav tshuaj tiv thaiv kab mob. Piv txwv li, somatostatin tau siv los kho cov qog endocrine ntawm lub plab zom mov; Cov kws tshawb fawb Asmeskas pom muaj hexapeptide uas tuaj yeem cuam tshuam adenocarcinoma hauv vivo; Cov kws tshawb fawb Swiss tau tshawb pom ib qho octapeptide uas ua rau apoptosis hauv cov qog hlwb.
Antiviral polypeptide
Los ntawm kev khi rau cov receptors tshwj xeeb ntawm cov tswv tsev, cov kab mob adsorb hlwb thiab tso siab rau lawv tus kheej cov proteases rau kev ua cov protein thiab nucleic acid replication. Yog li ntawd, peptides khi rau host cell receptors los yog cov chaw nquag xws li kab mob proteases tuaj yeem raug tshuaj xyuas los ntawm lub tsev qiv ntawv peptide rau kev kho tshuaj tiv thaiv kab mob. Hauv xyoo 2013, Canada, Ltalis thiab lwm lub tebchaws tau tshuaj xyuas ntau cov peptides me me nrog cov kab mob tiv thaiv los ntawm lub tsev qiv ntawv peptide, thiab qee qhov ntawm lawv tau nkag mus rau theem ntawm kev sim tshuaj. Nyob rau lub Rau Hli 2004, lub koom haum ntawm Microbiology, Suav Academy ntawm Sciences tau tshaj tawm tias cov kev taw qhia tseem ceeb ntawm kev paub innovation project ua los ntawm lub koom haum ntawm Microbiology, Suav Academy ntawm Sciences, "Kev tshawb fawb ntawm lub mechanism ntawm SARS-CoV cell fusion thiab Fusion inhibitors", uas tau koom ua ke los ntawm Lub Tsev Haujlwm ntawm Microbiology, Suav Academy ntawm Kev Tshawb Fawb thiab Lub Chaw rau Niaj Hnub Nyoog Virology, Lub Neej Kev Tshawb Fawb, Wuhan University, tau ua tiav qhov tseem ceeb. Cov kev sim tau ua pov thawj tias tus tsim HR2 peptide tuaj yeem tiv thaiv kab mob ntawm cov kab mob ntawm cov kab mob los ntawm SARS tus kab mob, thiab qhov ua tau zoo inhibition concentration yog nyob rau ntawm ntau nmoles. Cov kev vam meej tseem ceeb kuj tau ua nyob rau hauv cov kab mob kis kab mob inhibition thwmsim ntawm synthesized thiab qhia HR1 peptide thiab hauv vitro binding thwmsim ntawm HR1 thiab HR2. Cov tshuaj peptide tsim los tiv thaiv kev sib xyaw ntawm tus kab mob SARS tuaj yeem tiv thaiv kev kis tus kab mob thiab, nyob rau hauv cov ntaub ntawv ntawm cov neeg mob, tiv thaiv kev kis tus kab mob ntxiv hauv lub cev. Cov tshuaj polypeptide muaj ob qho tib si tiv thaiv thiab kho kev ua haujlwm. Cov kws tshawb fawb ntawm Cell Engineering Research Center ntawm Lub Tsev Haujlwm Saib Xyuas Tub Rog Plaub Ntug tau tsim cuaj peptides uas tuaj yeem tiv thaiv tau zoo thiab cuam tshuam kev cuam tshuam ntawm tus kab mob SARS rau hauv cov hlwb.
Cytokines ua raws li peptides
Kev siv cov receptors paub txog cytokines los tshuaj xyuas cytokine mimics los ntawm cov tsev qiv ntawv peptide tau dhau los ua qhov kev tshawb fawb hotspot nyob rau hauv 2011. Kev tshuaj xyuas los ntawm cov neeg txawv teb chaws erythropoietin, cov neeg boost platelet hormone, kev loj hlob hormone, paj hlwb loj hlob thiab ntau yam kev loj hlob yam xws li interleukin - 1 simulation peptide, qhov simulation ntawm peptide amino acid ib ntus thiab nws cov khoom sib txuas ntawm tes sib txawv, cov kab ke ntawm cov amino acids tab sis muaj cov haujlwm ntawm cytokines, thiab muaj qhov zoo ntawm me me.molecular hnyav. Nyob rau hauv 2013 cov cytokine mimicking peptides yog nyob rau hauv preclinical los yog soj ntsuam soj ntsuam.
Antibacterial active peptide
Thaum cov kab raug txhawb los ntawm ib puag ncig sab nraud, ntau cov cationic peptides nrog cov tshuaj tua kab mob yog tsim. Hauv xyoo 2013, ntau tshaj 100 hom tshuaj tiv thaiv kab mob peptides tau raug tshuaj xyuas. Hauv vitro thiab hauv vivo thwmsim tau lees paub tias ntau cov tshuaj tua kab mob peptides tsis tsuas yog muaj peev xwm tiv thaiv kab mob thiab kab mob, tab sis kuj tuaj yeem tua cov qog hlwb.
Tshuaj tiv thaiv Peptide
Cov tshuaj tiv thaiv Peptide thiab tshuaj tiv thaiv nucleic acid yog ib qho tseem ceeb tshaj plaws hauv kev tshawb fawb tshuaj tiv thaiv hauv xyoo 2013. Ntau qhov kev tshawb fawb thiab kev tsim cov tshuaj tiv thaiv kab mob peptide tau ua nyob hauv ntiaj teb xyoo 2013. Piv txwv li, xyoo 1999, NIH luam tawm cov soj ntsuam cov txiaj ntsig ntawm ob hom kab mob HIV-I cov tshuaj tiv thaiv kab mob peptide rau tib neeg; Ib qho polypeptide tau soj ntsuam los ntawm cov txheej txheem membrane E2 ntawm tus kab mob siab C (HCV), uas tuaj yeem txhawb lub cev los tsim cov tshuaj tiv thaiv. Tebchaws Meskas tab tom tsim tshuaj tiv thaiv kab mob malaria polyvalent antigen polypeptide; Tib neeg papillomavirus peptide txhaj tshuaj tiv thaiv kab mob qog noj ntshav tau nkag mus rau theem II kev sim tshuaj. Tuam Tshoj kuj tau ua haujlwm ntau hauv kev tshawb fawb txog ntau yam tshuaj tiv thaiv polypeptide.
Peptides rau kev kuaj mob
Kev siv lub ntsiab ntawm peptides hauv kev kuaj mob reagents yog raws li antigens, tshuaj tiv thaiv kab mob txhawm rau txheeb xyuas cov kab mob sib kis. Polypeptide antigens yog qhov tshwj xeeb tshaj li cov kab mob microbial lossis parasitic protein antigens thiab yooj yim rau kev npaj. Antibody detection reagents tau sib sau ua ke nrog polypeptide antigens hauv xyoo 2013 suav nrog: A, B, C, G kab mob siab kab mob, HIV, human cytomegalovirus, herpes simplex virus, rubella virus, Treponema pallidum, cysticercosis, trypanosoma, Lyme disease thiab rheumatoid detection reagents. Feem ntau ntawm cov peptide antigens siv tau los ntawm cov protein ib txwm muaj ntawm cov kab mob sib xws, thiab qee qhov yog peptides tshiab tau los ntawm cov tsev qiv ntawv peptide.
