Hauv tib neeg lub cev, lub zog metabolism feem ntau yog nyob ntawm lub voj voog tricarboxylic acid, uas siv D-glucose ua ib yam khoom siv zog. Nyob rau hauv lub sij hawm ntev evolution, tib neeg lub cev tau tsim ib tug sophisticated thiab cov kab mob tshwj xeeb uas paub thiab metabolizes qabzib molecules. Nrog rau kev txhim kho ntawm tib neeg txoj kev ua neej nyob, ntshav qab zib, "tus neeg tua neeg uas ntsiag to", tau ua rau tib neeg kev noj qab haus huv txaus ntshai thiab coj lub nra hnyav rau hauv zej zog. Cov ntshav qabzib ntau zaus thiab txhaj tshuaj insulin ua rau cov neeg mob tsis xis nyob. Kuj tseem muaj peev xwm txaus ntshai xws li nyuaj rau kev tswj cov tshuaj txhaj tshuaj thiab kis kab mob ntshav. Yog li ntawd, kev txhim kho cov khoom siv biomaterials rau kev tso tawm cov ntse tswj kev tso tawm insulin yog ib qho kev daws teeb meem zoo tshaj plaws kom ua tiav kev tswj cov ntshav qabzib mus ntev hauv cov neeg mob ntshav qab zib.

Muaj ntau hom piam thaj isomers nyob rau hauv ob qho tib si zaub mov thiab lub cev kua dej ntawm tib neeg lub cev. Cov enzymes lom neeg ntawm tib neeg lub cev tuaj yeem paub meej cov piam thaj molecules thiab muaj qib siab ntawm qhov tshwj xeeb. Txawm li cas los xij, hluavtaws chemistry muaj kev paub txog cov piam thaj molecules. Cov qauv yog qhov nyuaj heev. Qhov no yog vim hais tias cov qauv molecular ntawm cov piam thaj molecules thiab nws cov isomers (xws li galactose, fructose, thiab lwm yam) zoo sib xws, thiab lawv tsuas muaj ib pawg hydroxyl ua haujlwm xwb, uas nyuaj rau kev txheeb xyuas qhov tseeb. Ob peb cov tshuaj ligands uas tau tshaj tawm tias muaj peev xwm lees paub cov piam thaj tshwj xeeb yuav luag txhua tus muaj teeb meem xws li cov txheej txheem sib xyaw ua ke nyuaj.

Tsis ntev los no, pab neeg ntawm xibfwb Yongmei Chen thiab Associate Professor Wang Renqi ntawm Shaanxi University of Science thiab Technology tau koom tes nrog Associate Professor Mei Yingwu ntawm Zhengzhou University los tsim ib hom tshiab raws li bidentate-β- Hydrogel system ntawm cyclodextrin. Los ntawm kev qhia meej ib khub ntawm phenylboronic acid hloov cov pab pawg ntawm 2,6-dimethyl-β-cyclodextrin (DMβCD), ib qho molecular slit ua raws li cov qauv topological ntawm D-glucose yog tsim, uas tuaj yeem ua ke nrog D- Glucose molecules khi. thiab tso tawm protons, ua rau hydrogel o, yog li ua rau cov tshuaj insulin preloaded hauv hydrogel kom sai sai tso rau hauv cov ntshav ib puag ncig. Kev npaj ntawm bidentate-β-cyclodextrin tsuas yog xav tau peb kauj ruam ntawm cov tshuaj tiv thaiv, tsis tas yuav muaj kev sib txuam hnyav, thiab cov tshuaj tiv thaiv tawm los yog siab. Lub hydrogel loaded nrog bidentate-β-cyclodextrin sai sai teb rau hyperglycemia thiab tso tawm cov tshuaj insulin hauv hom I ntshav qab zib nas, uas tuaj yeem ua tiav kev tswj cov ntshav qabzib mus ntev li ntawm 12 teev.